Fig. 5
From: Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes
Increased NK, CD8+ T-cell and cytotoxicity levels are associated with mutations in MHC-I. a and c and e Boxplots comparing MSS TCGA patients with or without B2M or HLA mutations, in terms of their (a) CD8+ T cell levels, (c) natural killer (NK) cell levels, and (e) cytotoxicity scores. Sample sizes for each patient group are written under their name. b and d and f) Boxplots comparing MSS TCGA patients with or without B2M or HLA mutations, in terms of their (b) CD8+ T cell levels, (d) natural killer (NK) cell levels, and (f) cytotoxicity scores. Patients are divided by tumor type and only the tumor types with at least 5 mutated patients are shown. P-values are adjusted for multiple comparisons. Sample sizes for each patient group are written under the tissue name