Table 1 Comparison between AmpliSolve and SiNVICT calls across the targeted panel. MutPlat calls on Illumina WGS data have been used as ground-truth. SiNVICT levels correspond to confidence levels in the calls (6 being the highest). TP = True Positives, FP=False Positives, FN = False Negatives, TPR = True Positives Rate (Sensitivity), PPV=Positive Predictive Value (Precision), F1 = Harmonic mean of Precision and Sensitivity
| Â | TP | FP | FN | TPR | PPV | F1 | |
|---|---|---|---|---|---|---|---|
AmpliSolve | Â | 525 | 31 | 78 | 87% | 94% | 90% |
SiNVICT | Level 1 | 591 | 156 | 12 | 98% | 79% | 88% |
Level 2 | 587 | 154 | 16 | 97% | 79% | 87% | |
Level 3 | 575 | 34 | 28 | 95% | 94% | 95% | |
Level 4 | 575 | 34 | 28 | 95% | 94% | 95% | |
Level 5 | 141 | 12 | 457 | 24% | 92% | 38% | |
Level 6 | 104 | 3 | 494 | 17% | 97% | 29% | |