Fig. 1

Genetic background modulates refractive eye development and susceptibility to myopia in mice. a Refractive error is inherited as a quantitative trait in the founder strains of Collaborative Cross. Baseline refractive errors at P40 range from highly myopic to highly hyperopic depending on the genetic background in different strains. Horizontal red lines show mean refractive errors for each strain, while each dot corresponds to mean refractive errors of individual animals. b Susceptibility to form-deprivation myopia is inherited as a quantitative trait in the founder strains of Collaborative Cross. The extent of myopia induced by 21 days of visual form deprivation in different strains ranged from − 5.5 ± 2.1 D in NZO/HlLtJ mice to − 18.7 ± 3.1 D in CAST/EiJ mice. Horizontal red lines identify means of induced myopia for each strain, while each dot represents a mean interocular difference between the deprived eye and control contralateral eye for individual animals