Table 1 Summary of the novel severe malaria susceptibility and resistance association variants identified by GWASs
Genomic regions containing the association variants | Â | Genome-wide association studies | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Jallow et.al [10] Pop: Gambian N = 2560(case =1060, control = 1500) | Timmann et al. [11] Pop: Ghanaian N = 2153 (case =1325, control =828) | Band et al. [12] Pop: African (11 countries) N = 11,552 (case = 5633, control = 5919) | Ravenhall et al. [13] Pop: Tanzanian N = 914 case =449, control = 465) | |||||||||
Nearest gene name | Chr | Position | SNP ID (Ref/Alt) | MOI | OR | p-value | OR | P-value | OR | P-value | OR | P-value |
ATP2B4 | 01 | 203658471 | rs 4951377 (A/G) | DO | – | – | – | – | – | 3.1x10−9 | – | – |
203654024 | rs 10900585(T/G) | AD | – | – | 0.61 | 1.9 × 10−10 | – | – | – | – | ||
203660781 | rs4951074(G/A) | AD | – | – | 0.62 | 1.3 × 10−9 | – | – | – | – | ||
IL23R, IL12RB | 01 | 67,731,614 | rs6682413(−) | RE | – | – | – | – | – | – | 0.48 | 8 × 10−7 |
GYP A/B/E and FREM3 | 04 | 143777125 | rs184895969(A/C) | DO | – | – | – | – | 0.67 | 9.5 × 10−11 | - | - |
C4orf17 | 04 | 100429757 | rs73832816(−) | REC | – | – | – | – | – | – | 0.29 | 3.8 × 10− 7 |
AF146191.4–004 (lincRNA) | 04 | 90717704 | rs114169033(−) | AD | - | - | - | - | - | - | 3.32 | 6.7 × 10−7 |
AC108142.1 (antisense) | 04 | 82822332 | rs1878468 | HET | - | - | - | - | - | - | 0.383 | 9.0 × 10−7 |
Intergenic | 05 | 43,909,343 | rs113449872(−) | HET | – | – |  | – | – | – | 0.35 | 2.2 × 10−8 |
KLHL3, MYOT | 05 | 37,011,761 | rs2967790(−) | AD | – | – | – | – | – | – | 0.60 | 5.9 × 10−7 |
TREML4 | 06 | 41,205,690 | rs9296359 (−) | HET | – | – | – | – | – | – | 4.08 | 1.2 × 10−7 |
DDC | 07 | 50,623,201 | rs10249420(C/G) | AD | 0.69 | 6.8 × 10−5 | – | – | – | – | – | – |
|  |  | rs1451375(−) | DO | 0.75 | 6.1x10−6 | – | – | – | – | – | – | |
Intergenic | 07 | 53,676,837 | rs17624383(−) | AD | – | – | – | – | – | – | – | 5.6 × 10−7 |
CSMD1 | 08 | 4754838 | rs73505850(−) | AD |  | – | – | – | – | – | 4.79 | 5.9 × 10− 7 |
LINC00944 | 12 | 127237620 | rs11335470 (−) | HET | – | – | – | – | – | – | 0.40 | 2.5 × 10−7 |
Intergenic | 11 | 130,417,522 | rs3133394 | AD |  |  |  |  |  |  | 0.5 | 9.4X10−7 |
FAM155A | 13 | 108228013 | rs144312179(−) | AD | – | – | – | – | – | – | 0.2 | 6.2 × 10−7 |
MARVELD3 | 16 | 71,653,637 | rs2334880 (T/C) | AD | – | – | 1.19 | 1.9 × 10−6 | – | – | – | – |
SOC1 | 17 | 10,573,909 | rs65033119(−) | AD | 1.21 | 7.2 × 10−7 | – | – | – | – | – | – |
Intergenic (LINC00670) | 17 | 12,399,526 | rs149085856(−) | AD | – | – | – | – | – | – | 3.87 | 2.1x10−7 |
ZNF536 | 19 | 1,069,639 | rs8109875(−) | REC | – | – | – | – | – | – | 0.5 | 5.7 × 10−7 |