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Table 1 Summary of the novel severe malaria susceptibility and resistance association variants identified by GWASs

From: Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

Genomic regions containing the association variants   Genome-wide association studies
Jallow et.al [10]
Pop: Gambian
N = 2560(case =1060, control = 1500)
Timmann et al. [11]
Pop: Ghanaian
N = 2153 (case =1325, control =828)
Band et al. [12]
Pop: African (11 countries)
N = 11,552 (case = 5633, control = 5919)
Ravenhall et al. [13]
Pop: Tanzanian
N = 914 case =449, control = 465)
Nearest gene name Chr Position SNP ID
(Ref/Alt)
MOI OR p-value OR P-value OR P-value OR P-value
ATP2B4 01 203658471 rs 4951377 (A/G) DO 3.1x10−9
203654024 rs 10900585(T/G) AD 0.61 1.9 × 10−10
203660781 rs4951074(G/A) AD 0.62 1.3 × 10−9
IL23R, IL12RB 01 67,731,614 rs6682413(−) RE 0.48 8 × 10−7
GYP A/B/E and FREM3 04 143777125 rs184895969(A/C) DO 0.67 9.5 × 10−11 - -
C4orf17 04 100429757 rs73832816(−) REC 0.29 3.8 × 10− 7
AF146191.4–004 (lincRNA) 04 90717704 rs114169033(−) AD - - - - - - 3.32 6.7 × 10−7
AC108142.1 (antisense) 04 82822332 rs1878468 HET - - - - - - 0.383 9.0 × 10−7
Intergenic 05 43,909,343 rs113449872(−) HET   0.35 2.2 × 10−8
KLHL3, MYOT 05 37,011,761 rs2967790(−) AD 0.60 5.9 × 10−7
TREML4 06 41,205,690 rs9296359 (−) HET 4.08 1.2 × 10−7
DDC 07 50,623,201 rs10249420(C/G) AD 0.69 6.8 × 10−5
   rs1451375(−) DO 0.75 6.1x10−6
Intergenic 07 53,676,837 rs17624383(−) AD 5.6 × 10−7
CSMD1 08 4754838 rs73505850(−) AD   4.79 5.9 × 10− 7
LINC00944 12 127237620 rs11335470 (−) HET 0.40 2.5 × 10−7
Intergenic 11 130,417,522 rs3133394 AD        0.5 9.4X10−7
FAM155A 13 108228013 rs144312179(−) AD 0.2 6.2 × 10−7
MARVELD3 16 71,653,637 rs2334880 (T/C) AD 1.19 1.9 × 10−6
SOC1 17 10,573,909 rs65033119(−) AD 1.21 7.2 × 10−7
Intergenic (LINC00670) 17 12,399,526 rs149085856(−) AD 3.87 2.1x10−7
ZNF536 19 1,069,639 rs8109875(−) REC 0.5 5.7 × 10−7
  1. MIO Mode of inheritance, AD Additive, HET Heterozygous, DO Dominant, REC Recessive, OR Odd-ratio, Ref Reference allele, Alt Alternative allele, Pop Population