Fig. 3

Distributions of function index measuring the directional association from TSSs to cancer status. The red curve is the distribution of the index from representative TSSs of known cancer genes to cancer status. The blue curve is the distribution of representative TSSs of non-cancer genes to cancer status. Cancer gene TSSs apparently have more larger index values than non-cancer gene TSSs, implying that the former group is more powerful than the latter group at predicting cancer status. About 90% of known cancer gene representative TSSs have an index value of less than 0.40, as indicated by the vertical red dashed line