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Table 5 DAVID Functional annotation resultsa

From: Epigenetic landscapes suggest that genetic risk for intracranial aneurysm operates on the endothelium

Term

Source

No. of genes

P-Value

Q-Value

Serpin domain

INTERPRO

7

4.30E-10

4.90E-08

Serpin family

INTERPRO

7

4.30E-10

4.90E-08

SERPIN

SMART

7

9.00E-10

3.30E-08

Serine protease inhibitor

UP_KEYWORDS

7

4.20E-08

5.50E-06

Serine-type endopeptidase inhibitor activity

GOTERM_MF_DIRECT

7

1.80E-07

1.80E-05

Protease inhibitor

UP_KEYWORDS

7

3.70E-07

2.50E-05

Negative regulation of endopeptidase activity

GOTERM_BP_DIRECT

6

1.20E-05

4.80E-03

Extracellular matrix structural constituent

GOTERM_MF_DIRECT

5

2.70E-05

1.40E-03

Protease inhibitor I4, serpin, conserved site

INTERPRO

4

7.40E-05

4.20E-03

Extracellular space

GOTERM_CC_DIRECT

13

9.30E-05

1.00E-02

Extracellular matrix

GOTERM_CC_DIRECT

7

9.50E-05

5.20E-03

Extracellular matrix organization

GOTERM_BP_DIRECT

6

1.20E-04

2.40E-02

Propeptide: C-terminal propeptide

UP_SEQ_FEATURE

3

1.40E-04

3.80E-02

Domain: Fibrillar collagen NC1

UP_SEQ_FEATURE

3

2.80E-04

3.70E-02

Extracellular matrix

UP_KEYWORDS

6

3.00E-04

1.30E-02

Fibrillar collagen, C-terminal

INTERPRO

3

3.30E-04

1.20E-02

Secreted

UP_KEYWORDS

14

3.30E-04

1.10E-02

Skeletal system development

GOTERM_BP_DIRECT

5

3.70E-04

4.70E-02

Ehlers-Danlos syndrome

UP_KEYWORDS

3

4.60E-04

1.20E-02

COLFI

SMART

3

4.70E-04

8.60E-03

  1. aFunctional annotation results returned from DAVID using genes within ±200 kb of intracranial aneurysm-associated linkage disequilibrium blocks. Abbreviations: DAVID Database for Annotation, Visualization and Integrated Discovery; No. Number