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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Transcriptome analysis identified a novel 3-LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy

Fig. 3

Significantly differential lncRNAs and mRNAs in glucose and TTR treated hRECs. The significantly DE-lncRNAs and DE-mRNAs were shown in volcano plot. a DE-lncRNAs and DE-mRNAs in HG group compared with LG group; b DE-lncRNAs and mRNAs in HG + TTR group compared with HG group. Significantly highly expressed genes (lncRNAs and mRNAs) were defined as genes with the value of fold change> = 2, P value<=0.05 and FDR < =0.05, were shown in red dots; significantly low expressed genes (lncRNAs and mRNAs) were defined as genes with the value of fold change<=0.5, P value<=0.05 and FDR < =0.05, and shown in green dots. Genes didn’t meet the criteria were shown in grey dots. After TTR-DGEs identification, hierarchical clustering and heatmap were used to show 853 mRNAs c) and 48 lncRNAs d) expression in 9 samples of 3 groups

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BMC Medical Genomics

ISSN: 1755-8794

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