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Fig. 8 | BMC Medical Genomics

Fig. 8

From: Transcriptome analysis identified a novel 3-LncRNA regulatory network of transthyretin attenuating glucose induced hRECs dysfunction in diabetic retinopathy

Fig. 8

LncRNA-mRNA regulatory network based on cis, trans and ceRNA relationship. a The cis lncRNA-mRNA regulatory network. Up-regulated TTR-DEGs were shown in red color and down-regulated TTR-DEGs were shown in green color. Grey color indicates genes not significantly expressed. TTR-mRNAs were represented in circle nodes and TTR-lncRNAs were shown in diamond nodes. The size of nodes indicates degree of centrality.. Edges in the network denote relative upstream or downstream location within 10 kb in the same chromosome. Red edges indicate upstream, blue indicates downstream and yellow edges indicate overlapping location of lncRNAs compared with mRNA. b The trans lncRNA-mRNA regulatory network. TTR-mRNAs were represented in circle nodes and TTR-lncRNAs were shown in diamond nodes. Edges color in the network denotes positive or negative correlation between lncRNA and mRNA expression. Edges in red color indicated positive expression Pearson correlation and green edges denotes negative expression Pearson correlation. c The lncRNA-miRNA-mRNA network. LncRNAs were shown in diamond nodes, TTR-mRNAs in circle nodes and miRNAs in triangle

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BMC Medical Genomics

ISSN: 1755-8794

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