Table 1 Clinical characteristics of pan-glioma splicing types
From: Classification of glioma based on prognostic alternative splicing
|  | pST1(n = 153) | pST2(n = 54) | pST3(n = 173) | pST4(n = 94) | pST5(n = 20) | pST6(n = 74) | pST7(n = 97) | Total(n = 154) |
|---|---|---|---|---|---|---|---|---|
Clinical | ||||||||
 Age | ||||||||
 Median | 60 | 57 | 38 | 38 | 50 | 40 | 43.5 | 47 |
Survival (in months) | ||||||||
 Median (CI) | 13.5 (12.1,15.3) | 20.2 (17.9, 27.1) | 94.5 (55.5, NA) | 88.7 (68.4132.6) | NA (32.1, NA) | 148.2 (74.5, NA) | 172.2 (76.1, NA) | 51.2 (44.6, 66.7) |
Karnofsky score | ||||||||
 100 | 12 | 4 | 30 | 17 | 2 | 4 | 17 | 86 |
 90 | 2 | 12 | 41 | 23 | 3 | 13 | 19 | 113 |
 70–80 | 69 | 11 | 15 | 10 | 3 | 12 | 10 | 130 |
  < 70 | 31 | 3 | 6 | 3 | 0 | 1 | 3 | 47 |
Sex | ||||||||
 Female | 54 | 26 | 53 | 38 | 9 | 35 | 38 | 253 |
 Male | 99 | 27 | 85 | 56 | 7 | 35 | 46 | 355 |
Grade | ||||||||
 G2 | 0 | 4 | 70 | 44 | 7 | 45 | 44 | 214 |
 G3 | 0 | 49 | 67 | 50 | 9 | 25 | 40 | 240 |
 G4 | 153 | 0 | 1 | 0 | 0 | 0 | 0 | 154 |
Histology | ||||||||
 Astrocytoma | 0 | 35 | 68 | 37 | 7 | 15 | 7 | 169 |
 Glioblastoma | 153 | 0 | 1 | 0 | 0 | 0 | 0 | 154 |
 Oligoastrocytoma | 0 | 9 | 39 | 25 | 3 | 18 | 19 | 113 |
 Oligodendroglioma | 0 | 9 | 30 | 32 | 6 | 37 | 58 | 172 |
Molecular | ||||||||
 IDH Status | ||||||||
  Mutant | 9 | 5 | 151 | 88 | 17 | 59 | 96 | 425 |
  WT | 140 | 49 | 21 | 5 | 3 | 14 | 1 | 233 |
 1P19Q | ||||||||
  Codel | 0 | 1 | 23 | 20 | 9 | 28 | 85 | 166 |
  Non-codel | 147 | 53 | 150 | 74 | 11 | 46 | 12 | 493 |
 TERT Expression Status | ||||||||
  Expressed | 127 | 39 | 40 | 20 | 12 | 27 | 82 | 347 |
  Not.expressed | 25 | 15 | 132 | 73 | 8 | 46 | 15 | 314 |
 ATRX Status | ||||||||
  Mutant | 8 | 6 | 94 | 53 | 4 | 21 | 9 | 195 |
  WT | 138 | 48 | 78 | 40 | 16 | 52 | 88 | 460 |
 CHR7.Gain.CHR10.loss | ||||||||
  Gain.chr7&loss.chr10 | 97 | 37 | 14 | 0 | 1 | 2 | 0 | 151 |
  No.combined. CNA | 50 | 17 | 159 | 93 | 19 | 70 | 97 | 505 |
 CHR19.20.co.gain | ||||||||
  Gain.chr19/20 | 19 | 6 | 3 | 0 | 0 | 2 | 0 | 30 |
  No.chr19/20.gain | 128 | 48 | 170 | 93 | 20 | 70 | 97 | 626 |
 MGMT Promoter | ||||||||
  Methylated | 51 | 25 | 147 | 78 | 16 | 63 | 94 | 474 |
  Unmethylated | 71 | 29 | 26 | 16 | 4 | 11 | 3 | 160 |
Clusters | ||||||||
 Transcriptome Cluster | ||||||||
  CL | 49 | 26 | 7 | 1 | 1 | 1 | 0 | 85 |
  MC | 66 | 16 | 8 | 6 | 1 | 0 | 0 | 97 |
  NE | 5 | 1 | 19 | 9 | 0 | 64 | 12 | 110 |
  PN | 18 | 3 | 72 | 61 | 7 | 4 | 69 | 234 |
 Original Cluster | ||||||||
  Classical | 39 | 0 | 0 | 0 | 0 | 0 | 0 | 39 |
  G-CIMP | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 8 |
  IDHmut-codel | 0 | 1 | 23 | 20 | 9 | 28 | 85 | 166 |
  IDHmut-non-codel | 0 | 4 | 127 | 67 | 8 | 31 | 11 | 248 |
  IDHwt | 0 | 49 | 21 | 6 | 3 | 14 | 1 | 94 |
  Mesenchymal | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 50 |
  Neural | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 26 |
  Proneural | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 29 |
 Pan-Glioma RNA Expression Cluster | ||||||||
  LGr1 | 20 | 4 | 25 | 17 | 9 | 0 | 64 | 139 |
  LGr2 | 3 | 0 | 0 | 2 | 0 | 63 | 21 | 89 |
  LGr3 | 9 | 4 | 127 | 68 | 10 | 7 | 12 | 237 |
  LGr4 | 121 | 46 | 20 | 6 | 1 | 3 | 0 | 197 |
 Pan-Glioma DNA Methylation Cluster | ||||||||
  LGm1 | 7 | 4 | 18 | 11 | 2 | 7 | 3 | 52 |
  LGm2 | 1 | 0 | 120 | 59 | 7 | 38 | 27 | 252 |
  LGm3 | 0 | 1 | 14 | 19 | 8 | 14 | 66 | 122 |
  LGm4 | 43 | 14 | 4 | 0 | 1 | 3 | 0 | 65 |
  LGm5 | 59 | 30 | 12 | 0 | 1 | 2 | 0 | 104 |
  LGm6 | 12 | 5 | 5 | 5 | 1 | 10 | 1 | 39 |