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Table 1 Clinical characteristics of pan-glioma splicing types

From: Classification of glioma based on prognostic alternative splicing

  pST1(n = 153) pST2(n = 54) pST3(n = 173) pST4(n = 94) pST5(n = 20) pST6(n = 74) pST7(n = 97) Total(n = 154)
Clinical
 Age
 Median 60 57 38 38 50 40 43.5 47
Survival (in months)
 Median (CI) 13.5 (12.1,15.3) 20.2 (17.9, 27.1) 94.5 (55.5, NA) 88.7 (68.4132.6) NA (32.1, NA) 148.2 (74.5, NA) 172.2 (76.1, NA) 51.2 (44.6, 66.7)
Karnofsky score
 100 12 4 30 17 2 4 17 86
 90 2 12 41 23 3 13 19 113
 70–80 69 11 15 10 3 12 10 130
  < 70 31 3 6 3 0 1 3 47
Sex
 Female 54 26 53 38 9 35 38 253
 Male 99 27 85 56 7 35 46 355
Grade
 G2 0 4 70 44 7 45 44 214
 G3 0 49 67 50 9 25 40 240
 G4 153 0 1 0 0 0 0 154
Histology
 Astrocytoma 0 35 68 37 7 15 7 169
 Glioblastoma 153 0 1 0 0 0 0 154
 Oligoastrocytoma 0 9 39 25 3 18 19 113
 Oligodendroglioma 0 9 30 32 6 37 58 172
Molecular
 IDH Status
  Mutant 9 5 151 88 17 59 96 425
  WT 140 49 21 5 3 14 1 233
 1P19Q
  Codel 0 1 23 20 9 28 85 166
  Non-codel 147 53 150 74 11 46 12 493
 TERT Expression Status
  Expressed 127 39 40 20 12 27 82 347
  Not.expressed 25 15 132 73 8 46 15 314
 ATRX Status
  Mutant 8 6 94 53 4 21 9 195
  WT 138 48 78 40 16 52 88 460
 CHR7.Gain.CHR10.loss
  Gain.chr7&loss.chr10 97 37 14 0 1 2 0 151
  No.combined. CNA 50 17 159 93 19 70 97 505
CHR19.20.co.gain
  Gain.chr19/20 19 6 3 0 0 2 0 30
  No.chr19/20.gain 128 48 170 93 20 70 97 626
 MGMT Promoter
  Methylated 51 25 147 78 16 63 94 474
  Unmethylated 71 29 26 16 4 11 3 160
Clusters
 Transcriptome Cluster
  CL 49 26 7 1 1 1 0 85
  MC 66 16 8 6 1 0 0 97
  NE 5 1 19 9 0 64 12 110
  PN 18 3 72 61 7 4 69 234
 Original Cluster
  Classical 39 0 0 0 0 0 0 39
  G-CIMP 7 0 1 0 0 0 0 8
  IDHmut-codel 0 1 23 20 9 28 85 166
  IDHmut-non-codel 0 4 127 67 8 31 11 248
  IDHwt 0 49 21 6 3 14 1 94
  Mesenchymal 50 0 0 0 0 0 0 50
  Neural 26 0 0 0 0 0 0 26
  Proneural 29 0 0 0 0 0 0 29
 Pan-Glioma RNA Expression Cluster
  LGr1 20 4 25 17 9 0 64 139
  LGr2 3 0 0 2 0 63 21 89
  LGr3 9 4 127 68 10 7 12 237
  LGr4 121 46 20 6 1 3 0 197
 Pan-Glioma DNA Methylation Cluster
  LGm1 7 4 18 11 2 7 3 52
  LGm2 1 0 120 59 7 38 27 252
  LGm3 0 1 14 19 8 14 66 122
  LGm4 43 14 4 0 1 3 0 65
  LGm5 59 30 12 0 1 2 0 104
  LGm6 12 5 5 5 1 10 1 39