Table 3 Enriched pathways using ConsensusPathDB
From: Significant random signatures reveals new biomarker for breast cancer
Gene Name | Main functions | Included related pathway | Cancer type | Citations |
|---|---|---|---|---|
TAT | Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Pro-apoptotic effect through the mitochondrial pathway | Metabolism and carbon metabolism pathways in Mitochondria | Hepatocellular carcinomas (HCC), small cell carcinoma | [41] |
BIRC5 | Dual roles in promoting cell proliferation and preventing apoptosis. Essential for chromosome alignment and segregation during mitosis and cytokinesis. Participates in the organization of the center spindle by associating with polymerized microtubules. | Apoptosis, cell cycle, Immune system modulation | Breast, prostate, bladder, lung, colorectal, ovarian, cervical cancer and others | [42] |
PHYHD1 | Alpha-ketoglutarate-dependent dioxygenase activity | Peroxisomal phytanic acid alpha-oxidation pathway | Prostate cancer | [43] |
SEC14L2 | Carrier protein. May have a transcriptional activator activity via its association with alpha-tocopherol. May regulate cholesterol biosynthesis. | Transcription | Breast and prostate cancer | |
TK1 | Catalyzes the addition of a gamma-phosphate group to thymidine. Biosyntehsis of dTTP, required for DNA replication. | Cell Cycle, Mitotic and Metabolism | Breast and prostate cancer | [30] |
ZNF385B | Role in p53/TP53-mediated apoptosis. | Apoptotis | Breast and ovarian cancer | [35] |
CLIC6 | May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport | Activation of cAMP-Dependent PKA, Hepatic ABC Transporters | Breast cancer | [47] |
TCIM | Involved in the regulation of cell growth and differentiation. Involved in the regulation of heat shock response. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). | Apoptosis | Thyroid, breast, gastric, liver and lung cancer | |
ELOVL1 | Fatty acids elongation | Metabolism and Regulation of lipid metabolism | Cancers | [31] |
TFF1 | Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. | Estrogen signaling pathway, adhesion | Breast and gastric cancer |