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Table 3 Enriched pathways using ConsensusPathDB

From: Significant random signatures reveals new biomarker for breast cancer

Gene NameMain functionsIncluded related pathwayCancer typeCitations
TATTransaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Pro-apoptotic effect through the mitochondrial pathwayMetabolism and carbon metabolism pathways in MitochondriaHepatocellular carcinomas (HCC), small cell carcinoma[41]
BIRC5Dual roles in promoting cell proliferation and preventing apoptosis. Essential for chromosome alignment and segregation during mitosis and cytokinesis. Participates in the organization of the center spindle by associating with polymerized microtubules.Apoptosis, cell cycle, Immune system modulationBreast, prostate, bladder, lung, colorectal, ovarian, cervical cancer and others[42]
PHYHD1Alpha-ketoglutarate-dependent dioxygenase activityPeroxisomal phytanic acid alpha-oxidation pathwayProstate cancer[43]
SEC14L2Carrier protein. May have a transcriptional activator activity via its association with alpha-tocopherol. May regulate cholesterol biosynthesis.TranscriptionBreast and prostate cancer[4446]
TK1Catalyzes the addition of a gamma-phosphate group to thymidine. Biosyntehsis of dTTP, required for DNA replication.Cell Cycle, Mitotic and MetabolismBreast and prostate cancer[30]
ZNF385BRole in p53/TP53-mediated apoptosis.ApoptotisBreast and ovarian cancer[35]
CLIC6May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transportActivation of cAMP-Dependent PKA, Hepatic ABC TransportersBreast cancer[47]
TCIMInvolved in the regulation of cell growth and differentiation. Involved in the regulation of heat shock response. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity).ApoptosisThyroid, breast, gastric, liver and lung cancer[43, 48, 49]
ELOVL1Fatty acids elongationMetabolism and Regulation of lipid metabolismCancers[31]
TFF1Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.Estrogen signaling pathway, adhesionBreast and gastric cancer[50, 51]