Table 1 Cociter analysis of top 30 lung cancer driver genes identified by our method
Genes | Cancer | Lung | Driver | Is_driver | DyTidriver | Diffusion | DriverNet | DawnRank | Muf_max | Muf_sum |
|---|---|---|---|---|---|---|---|---|---|---|
TP53 | 6772 | 999 | 110 | 1 | 1 | 20 | 1 | 1 | 5 | 6 |
ZNF536 | 4 | 0 | 1 | 1 | 2 | 5015 | NA | 2689 | 849 | 79 |
EGFR | 4748 | 2849 | 166 | 1 | 3 | 1 | 3 | 4 | 7 | 26 |
TSHZ3 | 4 | 1 | 1 | 0 | 4 | 2748 | 1295 | 2463 | 1268 | 188 |
PRUNE2 | 12 | 1 | 1 | 0 | 5 | 5211 | NA | 2623 | 2018 | 332 |
RYR2 | 4 | 3 | 2 | 0 | 6 | 757 | 20 | 558 | 128 | 25 |
SPTA1 | 3 | 2 | 1 | 0 | 7 | 221 | 6 | 15 | 12 | 36 |
ATP10D | 1 | 0 | 0 | 0 | 8 | 1836 | NA | 2825 | 2667 | 873 |
ANKIB1 | 2 | 1 | 0 | 0 | 9 | 1607 | NA | 2572 | 4107 | 2080 |
ZNF521 | 2 | 0 | 1 | 1 | 10 | 5025 | NA | 3058 | 1906 | 302 |
NES | 192 | 31 | 5 | 0 | 11 | 1483 | NA | 1461 | 3094 | 1138 |
PIK3CA | 1199 | 183 | 54 | 1 | 12 | 2 | 5 | 112 | 430 | 81 |
TLR4 | 417 | 591 | 9 | 1 | 13 | 71 | 45 | 3 | 672 | 138 |
NF1 | 165 | 16 | 11 | 1 | 14 | 34 | 56 | 21 | 389 | 139 |
FAT4 | 45 | 7 | 2 | 0 | 15 | 3106 | 839 | 1961 | 970 | 119 |
ASH1L | 4 | 1 | 1 | 0 | 16 | 1506 | NA | 2289 | 2549 | 761 |
PRKCB | 41 | 11 | 1 | 1 | 17 | 5 | 12 | NA | 442 | 92 |
SLC12A1 | 2 | 2 | 1 | 0 | 18 | 1647 | NA | 3038 | 4006 | 1750 |
CTNNB1 | 2517 | 340 | 44 | 1 | 19 | 6 | 21 | NA | 51 | 27 |
PLCB1 | 9 | 7 | 1 | 0 | 20 | 25 | 22 | 27 | 745 | 91 |
APOB | 27 | 4 | 2 | 0 | 21 | 117 | 7 | 8 | 664 | 42 |
MET | 1045 | 348 | 40 | 0 | 22 | 21 | 37 | 7 | 427 | 186 |
GRIN2B | 13 | 3 | 2 | 0 | 23 | 18 | 39 | 120 | 397 | 135 |
UBC | 134 | 17 | 2 | 0 | 24 | 3 | 4 | NA | 137 | 1 |
SASH1 | 13 | 3 | 1 | 0 | 25 | 1537 | NA | 1325 | 5100 | 3080 |
HGF | 393 | 174 | 7 | 0 | 26 | 47 | 84 | 40 | 398 | 1192 |
BRAF | 2175 | 270 | 126 | 1 | 27 | 70 | 75 | 155 | 392 | 150 |
UBA6 | 1 | 1 | 1 | 0 | 28 | 5263 | NA | NA | 2957 | 980 |
PTPRZ1 | 12 | 1 | 1 | 0 | 29 | 3366 | NA | 2402 | 894 | 289 |
TAF1L | 2 | 1 | 1 | 0 | 30 | 557 | 57 | 547 | 10 | 130 |