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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Interpretable deep neural network for cancer survival analysis by integrating genomic and clinical data

Fig. 5

Hierarchical and associational feature representation in Cox-PASNet. For instance, Jak-STAT signaling pathway shows active status, which is associated to PI. The significance of the genes (i.e. AKT1 and AKT3) involved in the Jak-STAT signaling pathway can be ranked by the average absolute partial derivatives with respect to the gene layer. A set of the active pathways are represented in an active Node 19 in the following hidden layers, which improves the survival prediction

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BMC Medical Genomics

ISSN: 1755-8794

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