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Table 5 External validation results.

From: A deep neural network approach to predicting clinical outcomes of neuroblastoma patients

Datasets

Balanced accuracy

Training

Test

DNN

SVM

RF

Clinical outcome = ‘Death from disease’,

 

Data = centralities

 

Fischer-M

Fischer-M

87.3%

75.4%

75.1%

 

Fischer-R

82.1%

53.5%

66.8%

 

Maris

53.1%

54.3%

50.0%

 

Versteeg

75.0%

53.3%

67.5%

Fischer-R

Fischer-R

85.8%

66.0%

62.4%

 

Fischer-M

81.5%

75.4%

61.2%

 

Maris

56.2%

49.7%

50.0%

 

Versteeg

70.8%

68.3%

67.5%

Clinical outcome = ‘Disease progression’,

 

Data = centralities

 

Fischer-M

Fischer-M

84.3%

83.7%

80.0%

 

Fischer-R

77.0%

75.2%

71.8%

 

Maris

67.5%

66.0%

53.8%

 

Versteeg

78.1%

82.4%

78.1%

Fischer-R

Fischer-R

83.7%

81.0%

73.3%

 

Fischer-M

80.0%

76.8%

75.0%

 

Maris

67.5%

58.8%

58.8%

 

Versteeg

80.1%

77.2%

73.9%

  1. Models are trained using one of the ‘Fischer’ datasets and then tested using either the other ‘Fischer’ dataset or another independent dataset (‘Maris’ and ‘Versteeg’). The ‘Maris’ and ‘Versteeg’ datasets are too small to be used for both training and therefore are only used for validation. Rows in italics represent reference models (training and testing extracted from the same datasets)