Fig. 3

Network and functional analysis of the three etiology groups comparison. a Protein-protein interaction network (highest confidence> 0.9) of the 143 genes (FDR < 0.05 and ΔPSI> 0.05) that are differentially expressed for the three group comparisons HBV vs. HCV, HCV vs. alcohol, and HBV vs. alcohol. Colors represent comparisons of differential AS events between etiology groups (HBV vs Alcohol, HCV vs Alcohol, and HBV vs HCV). The red circled dash shows a PPI network of the 29 genes (FDR < 0.05 and ΔPSI> 0.1) that are differentially expressed for the three group comparisons HBV vs. HCV, HCV vs. alcohol, and HBV vs. alcohol. b Significant pathways obtained by enrichment analysis in the CPDB database for 143 genes; immune system (FDR = 0.013), mRNA splicing-major pathway (FDR = 0.007), and nonsense-mediated decay (FDR = 0.003). PSI, percent spliced in; HBV, hepatitis B virus; HCV, hepatitis C virus; PPI, protein-protein interaction; AS, alternative splicing