Table 2 KEGG pathway analysis of differentially expressed genes associated with RMS

 hsa04110

Cell cycle

38

2.60631

3.62E-15

E2F3, E2F5, DBF4, TTK, CHEK1, CHEK2, PTTG1, CCNE2, CDC45, ORC6, CCNA2, CDC7, CDK1, CDC6, ANAPC4, SKP2, CDC23, ESPL1, CDC20, CDK6, MCM2, ATR, MCM3, CDK4, MCM5, SMC3, CDC25B, CCNB1, CCND1, HDAC2, CCNB2, MAD2L1, HDAC1, CCND2, PCNA, YWHAQ, BUB1B, GADD45A

 hsa04115

p53 signaling pathway

22

1.508916

1.41E-09

CDK1, ZMAT3, CHEK1, CDK6, ATR, CHEK2, PMAIP1, CDK4, CCNG2, GTSE1, CCNE2, CCNB1, TP53I3, CASP3, CCND1, CCNB2, CCND2, RRM2, BAX, DDB2, IGFBP3, GADD45A

 hsa04512

ECM-receptor interaction

22

1.508916

2.27E-07

COL4A2, COL4A1, TNC, COL3A1, COL2A1, ITGA4, COL5A2, COL5A1, HMMR, CD47, LAMA1, SDC1, LAMA5, COL6A3, COL1A2, COL1A1, SV2A, LAMB1, THBS2, COL11A1, SPP1, FN1

 hsa05200

Pathways in cancer

42

2.880658

0.003722

WNT5A, CKS1B, E2F3, GNAI3, GNAI1, PGF, FGF9, STK36, LPAR4, TCF7L2, EDNRA, CCNE2, FOS, CASP3, CXCR4, LAMB1, TRAF5, FN1, COL4A2, CTBP2, COL4A1, MSH2, SKP2, BRCA2, CDK6, BIRC5, FZD2, CDK4, DAPK1, LAMA1, NRAS, CCND1, HSP90B1, HIF1A, HDAC2, HDAC1, LAMA5, GNB1, BAX, CKS2, GNB4, F2R

 hsa05203

Viral carcinogenesis

26

1.783265

0.003088

CDK1, EGR3, EGR2, SKP2, GTF2H3, CDC20, CHEK1, CDK6, PMAIP1, CDK4, SCRIB, CCNE2, NRAS, CASP3, CCND1, HDAC2, HDAC1, CCND2, SND1, BAX, YWHAQ, RBPJ, TRAF5, HIST1H4J, CCNA2, RASA2

 hsa04261

Adrenergic signaling in cardiomyocytes

24

5.727924

2.18E-13

ATP1B1, CACNA2D1, PPP2R3A, SCN1B, MYL2, MYL3, TNNC1, ATP1B4, CACNB1, MYH7, MYH6, ATP1A2, TPM2, CACNG1, TNNI3, CACNA1S, TPM3, ADRB2, MAPK12, PLN, PPP1R1A, CAMK2B, CALML6, CAMK2A

 hsa04260

Cardiac muscle contraction

17

4.057279

1.03E-11

ATP1B1, CACNA2D1, MYL2, COX7A1, MYL3, TNNC1, ATP1B4, CACNB1, MYH7, ATP1A2, MYH6, CACNG1, TNNI3, TPM2, CACNA1S, TPM3, COX6A2

 hsa05410

Hypertrophic cardiomyopathy (HCM)

13

3.102625

2.09E-07

CACNA2D1, MYL2, MYL3, TNNC1, CACNB1, CACNG1, TNNI3, TTN, TPM2, CACNA1S, TPM3, SGCG, PRKAA2

 hsa05414

Dilated cardiomyopathy

13

3.102625

4.81E-07

CACNA2D1, MYL2, MYL3, TNNC1, CACNB1, CACNG1, TNNI3, TTN, TPM2, CACNA1S, TPM3, SGCG, PLN

 hsa04020

Calcium signaling pathway

18

4.295943

8.11E-07

TNNC2, SLC25A4, TNNC1, PHKG1, MYLK4, PHKA1, MYLK2, CACNA1S, VDAC1, GNAL, ADRB2, PLN, ATP2A1, RYR1, PLCD4, CAMK2B, CALML6, CAMK2A