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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Effects of ordered mutations on dynamics in signaling networks

Fig. 1

An example of mutation-sensitivity and order-specificity computation. Given a network G(V, A) with a set of wild-type update rules F, let v3 and v4 be a pair of nodes subject to a double-mutation with a time gap T, and 0100 S an initial state. FW denotes a W-mutant update rule set where every gene in WV is frozen. In this example, the wild-type attractor (Att1) is computed by applying F all the time. On the other hand, a (v3, v4)-ordered (or (v4, v3)-ordered) mutant attractor denoted by Att2 (resp. Att3) is computed by assuming that \( {F}^{\left\{{v}_3\right\}} \) (resp. \( {F}^{\left\{{v}_4\right\}} \)) and \( {F}^{\left\{{v}_3,{v}_4\right\}} \) apply for 0 ≤ t < T and T ≤ t, respectively. The mutation-sensitivity of (v3, v4)-ordered (or (v4, v3)-ordered) double-mutation is computed by comparing Att1 and Att2 (resp. Att3). The order-specificity is computed by comparing Att2 and Att3

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