Fig. 4

A significant correlation between cancer-specific AS events and DNA methylation at exon boundaries. a Column plot of the number of alternative splicing-related CpGs in different cancer types split according to type pf event. b Circos plot showing the distribution of methylation-associated splicing events across the human genome in ten solid tumors. The track outside the chromosome track showed the distribution of gene density across the genome. Inside tracks denote the Spearman correlation coefficient (ranging from − 1 to 1) between PSI and methylation level across the genome in each human tumor (from outside to inside): BRAC, COAD, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, THCA. c Common change of ZNF577 in five cancer types. Upper: Box plot of PSI values of exon 1.2 and 1.3 in ZNF577 in tumor and normal samples in five cancer types. Middle: Box plot of the methylation level of CpG site (cg11269599) in ZNF577 in tumor and normal samples in five cancer types. Lower: Scatter plot showing the significant relationship between PSI values and methylation levels in five cancer types