Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

Table 1 Splicing events and DNA methylation altered in the same direction in at least three cancer types

Gene name	Tumor types altered significantly	CpG site	Exon	Type of AS	The direction of the correlation
ZNF577	HNSC,KIRC,KIRP,LUSC,PRAD	cg11269599, cg10635122, cg03562414	1.2:1.3	RI	+
	KIRC,KIRP,PRAD	cg10783469, cg24794228, cg23010048, cg16731240	1.2:1.3	RI	+
EGFLAM	BRAC,HNSC,KIRC,THCA	cg21201393	1.2:1.3	RI	+
ANK3	COAD,LUAD,LUSC	cg22601415	20.1	AP	–
DNASE1L1	KIRC,KIRP,THCA	cg21459545	28	AP	–
LTB4R2	KIRC,LUSC,PRAD	cg07164388	3.1	AP	–
PIK3R1	HNSC,LUSC,THCA	cg25091228	1.2:1.3	RI	+
TNFRSF10C	HNSC,KIRC,KIRP,PRAD	cg14015044	9	AP	–

Abbreviations: BRAC Breast invasive carcinoma, HNSC Head, and neck squamous cell carcinoma, KIRC Kidney renal clear cell carcinoma, KIRP Kidney renal papillary carcinoma, LUAD Lung adenocarcinoma, LUSC Lung squamous cell carcinoma, PRAD Prostate adenocarcinoma, THCA Thyroid carcinoma, AS Alternative splicing, AP Alternate promoter, RI Retained intron, AT Alternate terminator
“+” represents the positive correlation between PSI values and DNA methylation in the tumor tissues. “-” represents the inverse correlation between PSI values and DNA methylation in the tumor tissues

ISSN: 1755-8794