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Table 1 Splicing events and DNA methylation altered in the same direction in at least three cancer types

From: Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

Gene name Tumor types altered significantly CpG site Exon Type of AS The direction of the correlation
ZNF577 HNSC,KIRC,KIRP,LUSC,PRAD cg11269599, cg10635122, cg03562414 1.2:1.3 RI +
  KIRC,KIRP,PRAD cg10783469, cg24794228, cg23010048, cg16731240 1.2:1.3 RI +
EGFLAM BRAC,HNSC,KIRC,THCA cg21201393 1.2:1.3 RI +
ANK3 COAD,LUAD,LUSC cg22601415 20.1 AP
DNASE1L1 KIRC,KIRP,THCA cg21459545 28 AP
LTB4R2 KIRC,LUSC,PRAD cg07164388 3.1 AP
PIK3R1 HNSC,LUSC,THCA cg25091228 1.2:1.3 RI +
  1. Abbreviations: BRAC Breast invasive carcinoma, HNSC Head, and neck squamous cell carcinoma, KIRC Kidney renal clear cell carcinoma, KIRP Kidney renal papillary carcinoma, LUAD Lung adenocarcinoma, LUSC Lung squamous cell carcinoma, PRAD Prostate adenocarcinoma, THCA Thyroid carcinoma, AS Alternative splicing, AP Alternate promoter, RI Retained intron, AT Alternate terminator
  2. “+” represents the positive correlation between PSI values and DNA methylation in the tumor tissues. “-” represents the inverse correlation between PSI values and DNA methylation in the tumor tissues