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Table 1 Main characteristics of base editing systems

From: Genome scale analysis of pathogenic variants targetable for single base editing

Name Cas protein Deaminase PAM Editing window Editing Efficiency Reference: Pubmed ID (Author, Year) Edited mutated nucleotides
APOBEC dCas9 APOBEC1 NGG −18 to −11 15–75% 27,096,365 (Komor, 2016) [6]  
SaBE3 SaCas9n APOBEC1 NNGRRT −15 to −9 5–65%   T > C
SaKKH-BE3 dCas9 APOBEC1 NNNRRT −17 to −9 10–65% 28,191,901 (Kim, 2017) [7]
EQR-Cas9 dCas9 APOBEC1 NGAG − 17 to − 10 10–40%
VRER-Cas9 dCas9 APOBEC1 NGCG −19 to −10 10–35%
VQR-Cas9 dCas9 APOBEC1 NGAN −17 to −10 10–60%
YE1-VQR-Cas9 dCas9 APOBEC1 NGAN −16 to −15 10–30%
A-BE3 dCas9 APOBEC1 NGG −17 to −12 20–50%
Y-BE3 dCas9 APOBEC1 NGG −17 to −13 10–30%
FE-BE3 dCas9 APOBEC1 NGG −16 to −14 10–40%
YEE-BE3 dCas9 APOBEC1 NGG −16 to −15 5–35%
PmCDA1 nCas9 PmCDA1 NGG −20 to −16 6–96% 27,492,474 (Nishida, 2016) [8]
BE-PLUS nCas9 APOBEC1 NGG −16 to −5 10–30% 29,875,396 (Jiang, 2018) [9]  
xCas9–BE3 xCas9 APOBEC1 NGN, GAW −17 to −13 10–24% 29,512,652 (Hu, 2018) [10]  
dCpf1-eBE dCpf1 APOBEC1 TTTV 8 to 13 15–30% 29,553,573
(Li, 2018) [11]
 
dCpf1-eBE-YE dCpf1 APOBEC1 TTTV 10 to 12 2–28%
APOBEC3A-Cas9 nCas9 APOBEC3A NGG −16 to −12 16–48% 30,059,493 (Gehrke, 2018) [12]
EA3A-BE3(VRQR) xCas9 APOBEC3A NGAN −17 to −10 15–63%
EA3A-BE3(xCas9) xCas9 APOBEC3A NGG, NGT −17 to −13 17–35%
BE-PAPAPAP nCas9 APOBEC1 NGG −16 to −15 24% 30,683,865 (Tan, 2019) [13]
cCDA1-BE3 nCas9 CDA1 NGG −19 to − 16 50%
xCas9–ABE xCas9 TadA NGV, GAT −17 to −13 16–69% 29,512,652 (Hu, 2018) [10] G > A
TadA dCas9 TadA NGG −17 to −12 25–75% 29,160,308 (Gaudelli, 2017) [14]