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Table 2 Numbers of mutations targetable by different base editors

From: Genome scale analysis of pathogenic variants targetable for single base editing

C > T Systems Number of mutations Number of potential sgRNAs
A-BE3 538 655
APOBEC 397 502
APOBEC3A-Cas9 115 403
BE_PLUS 181 229
EQR_Cas9 144 152
FE-BE3 714 822
PmCDA1 566 687
SaCas9 122 122
SaKKH_BE3 424 452
VQR_Cas9 485 530
VQR_Cas9_eA3A 766 766
VRER_Cas9 28 29
Y-BE3 599 722
YEE-BE3 720 791
dCpf1-eBE 136 136
dCpf1-eBE-YE 164 164
eA3A_xCas9 164 634
xCas9_BE3 2098 3001
Total number of mutations 3196  
A > G Systems
 TadA 2568 3235
 xCas9_ABE 6829 9638
Total number of mutations 6900  
  1. Some of the mutations can be targeted using more than one PAM, that’s why the number of potential sgRNAs can be bigger than the number of mutations