Table 2 Numbers of mutations targetable by different base editors
From: Genome scale analysis of pathogenic variants targetable for single base editing
C > T Systems | Number of mutations | Number of potential sgRNAs |
|---|---|---|
A-BE3 | 538 | 655 |
APOBEC | 397 | 502 |
APOBEC3A-Cas9 | 115 | 403 |
BE_PLUS | 181 | 229 |
EQR_Cas9 | 144 | 152 |
FE-BE3 | 714 | 822 |
PmCDA1 | 566 | 687 |
SaCas9 | 122 | 122 |
SaKKH_BE3 | 424 | 452 |
VQR_Cas9 | 485 | 530 |
VQR_Cas9_eA3A | 766 | 766 |
VRER_Cas9 | 28 | 29 |
Y-BE3 | 599 | 722 |
YEE-BE3 | 720 | 791 |
dCpf1-eBE | 136 | 136 |
dCpf1-eBE-YE | 164 | 164 |
eA3A_xCas9 | 164 | 634 |
xCas9_BE3 | 2098 | 3001 |
Total number of mutations | 3196 | |
A > G Systems | ||
TadA | 2568 | 3235 |
xCas9_ABE | 6829 | 9638 |
Total number of mutations | 6900 | |