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Table 2 Numbers of mutations targetable by different base editors

From: Genome scale analysis of pathogenic variants targetable for single base editing

C > T Systems

Number of mutations

Number of potential sgRNAs

A-BE3

538

655

APOBEC

397

502

APOBEC3A-Cas9

115

403

BE_PLUS

181

229

EQR_Cas9

144

152

FE-BE3

714

822

PmCDA1

566

687

SaCas9

122

122

SaKKH_BE3

424

452

VQR_Cas9

485

530

VQR_Cas9_eA3A

766

766

VRER_Cas9

28

29

Y-BE3

599

722

YEE-BE3

720

791

dCpf1-eBE

136

136

dCpf1-eBE-YE

164

164

eA3A_xCas9

164

634

xCas9_BE3

2098

3001

Total number of mutations

3196

 

A > G Systems

 TadA

2568

3235

 xCas9_ABE

6829

9638

Total number of mutations

6900

 
  1. Some of the mutations can be targeted using more than one PAM, that’s why the number of potential sgRNAs can be bigger than the number of mutations