Fig. 1

Genetic colocalization between blood traits reflects hematopoietic lineage relationships. a Number of traits identified at each colocalization site (max = 25). b Heat map depicting percent overlap at colocalization sites between each hematopoietic trait pair. In each box, the number of sites where the row-specified trait and column-specified trait colocalized was normalized to the total number of colocalization sites for the ‘row trait’. For this reason, the heat map is asymmetric. Color scale represents the proportion of loci where each pair of traits colocalized. To the left of the heat map, hierarchical clustering accurately segregated red cell, platelet, and white cell traits in general agreement with blood lineage relationships. c Degree of colocalization (% overlap) generally reflects genetic correlation between trait pairs. Shaded area depicts the 95% prediction interval, with gray line at mean. Colored spots highlight trait pairs outside the 95% prediction interval that included two platelet traits (purple) or two red blood cell traits (red). Exemplary trait pairs are circled. Eo % gran, percentage of granulocytes that are eosinophils. Neut % gran, percentage of granulocytes that are neutrophils. Plt, platelet count. Mpv, mean platelet volume. Mchc, mean corpuscular hemoglobin content. Mcv, mean red cell corpuscular volume. Neut, neutrophil count. Neut+eo, total neutrophil plus eosinophil count