Table 8 Strategies to retrieve the ground truth calls from the FF in the FFPE sample (UZ001)
From: Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples
Reported by … (in FFPE) | FF (gold std.) | FFPE | Overlap | Sensitivity | Precision | F1-score |
|---|---|---|---|---|---|---|
at least 1 caller | 4656 | 16,020 | 4155 | 0.8924 | 0.2594 | 0.4019 |
at least 2 callers | 4656 | 4232 | 3684 | 0.7912 | 0.8705 | 0.8290 |
at least 3 callers | 4656 | 340 | 325 | 0.0698 | 0.9559 | 0.1301 |
all 4 callers | 4656 | 8 | 8 | 0.0017 | 1 | 0.0034 |