Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

BMC Medical Genomics

Table 1 Statistical driver genes for advanced AMD identified with PARIS

Gene	Chromosome	Full Gene Name
C2	6	complement C2
MICA	6	MHC class I polypeptide-related sequence A
NOTCH4	6	notch receptor 4
RAD51B	14	RAD51 paralog B
LIPC	15	lipase C, hepatic type
*PLCG2*	16	phospholipase C gamma 2
C3	19	complement C3
*PPARA*	22	peroxisome proliferator activated receptor alpha

The eight statistical driver genes were identified with pathway analysis using PARIS and multiple biological pathway databases [14]. Two of these genes (PLCG2 and PPARA) were not previously identified as a part of the IAMDGC susceptibility loci and are noted in bold. Full gene names are based on the HUGO Gene Nomenclature Committee (HGNC)

ISSN: 1755-8794