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Table 7 Epistatic interactions between variants in or within 50 kb of PLCG2 and PPARA from pairwise logistic regression-based epistasis testing

From: Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

PLG2 Variants

PPARA Variants

Epistatic Interaction

Chr

Location (bp)

rsID

Locus Name

Chr

Location (bp)

rsID

Locus Name

OR

P

16

81,979,125

rs12921780

PLCG2

22

46,633,037

rs41479847

PPARA

1.38

0.00075

16

81,817,239

rs4580153

PLCG2

22

46,638,486

rs78864133

PPARA

1.16

0.00095

  1. Locations are given in base pairs (bp) based on build 37 of the human genome. Neither of these interactions are significant after correcting for multiple testing (p < 2.31 × 10−6). Chr: Chromosome, P: p-values from the logistic regression test, distributed as χ2 with 1 d.f
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BMC Medical Genomics

ISSN: 1755-8794

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