Fig. 2

Relation of TMB, MSI scores, and MMR protein expression. a TMB scores and ROC curve. b, c, d MSI score and ROC curve. Cases with positive MMR protein expression (MMR-P) exhibited lower TMB and MSI scores, but the MMR protein-deficient cases (MMR-D) significantly demonstrated higher scores for TMB (p < 0.001) and MSI (p < 0.001). The ROC curve was used to determine the cut-off scores for TMB-H and MSI-H as 31.1 and 4.2, respectively