Table 3 Shared GO processes between the subnetworks for PD and HGPS identified by the network analysis, but not related to subnetworks for AD or PM
GO term(s) | Network PD - key network objects | Seed nodes PD | Directionality PD | Network HGPS - key network objects | Seed nodes HGPS | Directionality HGPS |
|---|---|---|---|---|---|---|
GO:0042320: regulation of circadian sleep/wake cycle, REM sleep | SLC18A1, NDUFB3, MPPED2, Matrilin 3, CELSR1 | Galpha(q)-specific peptide GPCRs | down | GPR39, LCMT1, GLT25D2, BBS7, FAM126B | Galpha(q)-specific peptide GPCRs | both |
GO:0022410: circadian sleep/wake cycle process | AKAP12, Neurocan, Alpha-internexin, CBARA1, PR61beta | Galpha(q)-specific peptide GPCRs, Galpha(i)-specific peptide GPCRs | down | RY1, p42 KKIALRE, ITM2A, Tho2, C11orf1 | Galpha(q)-specific peptide GPCRs, Galpha(i)-specific peptide GPCRs | both |
GO:0007076: mitotic chromosome condensation | CDK5, Doublecortin, SNAP19, ELOVL4, LDHD | none | n/a | GPR39, LCMT1, GLT25D2, BBS7, FAM126B | CAP-G, CAPG/G2 | down |
GO:0060024: rhythmic synaptic transmission | SDHC, M9, NDUFB6, AGAL, CACNA2D2 | CACNA2D2, CACNA2D, Ca(II)channel R-type | down | VPS54, Rhophilin 2, RNF144, NDUFB6, FAM76B | none | n/a |
GO:0006370: 7-methylguanosine mRNA capping, GO:0009452: 7-methylguanosine RNA capping | MLF1, CCK8, PGMU, OATP-E, FLJ22028 | TBF5, TFIIH subunit | down, up | GSTM3, PDK (PDPK1), POLR2B, ATP6V0E2, C9orf16 | POLR2B | down |
GO:0014054: positive regulation of gamma-aminobutyric acid secretion | SNX4, LOH11CR2A, VPS41, MRPL46, ENDOGL1 | none | n/a | MASP1, FUT8, Cubilin, SNX25, ARL13B | none | n/a |
GO:0022900: electron transport chain | POLR3C, ATP1A4, nAChR beta-3, TMS-1, GATA-1 | NDUFA2, NDUFA3 | down | PPP1R3D, FOLR3, ERMAP, DNA polymerase sigma, WHDC1 | none | n/a |
GO:0070458: cellular detoxification of nitrogen compound | MANA, Rab-6B, LDB2, Exostosin-2, Rab-6 | GSTM1, GSTs | down | TUB, PLEKHM2, ZNF507, SH3PXD2B, GATA-1 | GSTs | up |
GO:0007166: cell surface receptor signaling pathway | Tcf(Lef), PLC-beta, G-protein beta/gamma, MEK4 (MAP2K4), PKR | MAP3K1, p38alpha, GSK3-beta, TCF7L2(TCF4), Tcf(Lef) | down(3), up(2) | JAK1, Axin, Frizzled, Jagged1, LRP5 | Dsh, SMAD3, TGF-beta 2, NOTCH1 receptor, FZD7, LRP6, NCOA3(pCIP/SRC3), RBP-J kappa(CBF1) | down(2), up(6) |
GO:0032956: regulation of actin cytoskeleton organization | DCTN6, PGRMC1, SEZ6L2, SCN9A, Cdc42 subfamily | RHO6, Cdc42 subfamily, Rho GTPase | down | PQLC1, TSHZ1, ZNF317, Cdc42 subfamily, FAN | SPTA1, Rho GTPase, Rac1, Rho3 | down(1), up(1), both(2) |
GO:0007167: enzyme-linked receptor protein signaling pathway | Ephrin-A, H-Ras, P13K reg class IA, Ephrin-A5, RHO6 | Ephrin-A receptor 8, H-Ras, Ephrin-A receptor 2 | down | ERK1/2, c-Src, VEGFR-2, JAK1, Ephrin-A | Ephrin-B, Ephrin-A receptor 2, Ephrin-A2, Ephrin-A | down(3), up(1) |