Table 1 Signaling pathways that Cluster 1 genes mainly enriched in
pathways | count | P value | Related GDEs in the network |
|---|---|---|---|
Cell Cycle, Mitotic | 31 | 2.76403E-29 | CENPE; KNTC1; KIF18A; TOP2A; MAD2L1; CCNB2; CKS1B; MCM4; CCNB1; PTTG1; NUF2; CDK1; AURKA; PLK1; TYMS; CCNA2; CDC20; NDC80; BUB1; CDC6; GINS2; CDC45; PLK4; CDCA8; KIF20A; RRM2; KIF2C; RFC4; KIF23; CENPF; NEK2; |
DNA Replication | 22 | 1.71367E-18 | CENPE; KNTC1; KIF18A; MAD2L1; MCM4; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; CDC6; GINS2; CDC45; PLK4; CDCA8; KIF20A; KIF2C; RFC4; KIF23; CENPF; NEK2; |
Mitotic M-M/G1 phases | 20 | 1.48601E-16 | CENPE; KNTC1; KIF18A; MAD2L1; MCM4; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; CDC6; CDC45; PLK4; CDCA8; KIF20A; KIF2C; KIF23; CENPF; NEK2; |
M Phase | 17 | 5.76137E-16 | CENPE; KNTC1; KIF18A; MAD2L1; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; PLK4; CDCA8; KIF20A; KIF2C; KIF23; CENPF; NEK2; |
Polo-like kinase signaling events in the cell cycle | 14 | 2.77681E-14 | CENPE; CCNB1; CDK1; AURKA; TPX2; ECT2; PLK1; PRC1; CDC20; NDC80; BUB1; PLK4; DLGAP5; KIF20A; |
PLK1 signaling events | 13 | 3.83583E-13 | CENPE; CCNB1; CDK1; AURKA; TPX2; ECT2; PLK1; PRC1; CDC20; NDC80; BUB1; DLGAP5; KIF20A; |
Mitotic Prometaphase | 12 | 5.11023E-12 | CENPE; KNTC1; KIF18A; MAD2L1; NUF2; PLK1; CDC20; NDC80; BUB1; CDCA8; KIF2C; CENPF; |
Cell Cycle Checkpoints | 11 | 1.32039E-08 | MAD2L1; CCNB2; MCM4; NDC80; CCNB1; CDK1; CDC20; CDC6; CDC45; RFC4; CHEK1; |
Signaling by Aurora kinases | 11 | 1.04137E-10 | NCAPH; NCAPG; AURKA; TPX2; NDC80; BUB1; CDCA8; DLGAP5; KIF20A; KIF2C; KIF23; |