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Table 1 Signaling pathways that Cluster 1 genes mainly enriched in

From: Bioinformatic analysis revealing mitotic spindle assembly regulated NDC80 and MAD2L1 as prognostic biomarkers in non-small cell lung cancer development

pathways count P value Related GDEs in the network
Cell Cycle, Mitotic 31 2.76403E-29 CENPE; KNTC1; KIF18A; TOP2A; MAD2L1; CCNB2; CKS1B; MCM4; CCNB1; PTTG1; NUF2; CDK1; AURKA; PLK1; TYMS; CCNA2; CDC20; NDC80; BUB1; CDC6; GINS2; CDC45; PLK4; CDCA8; KIF20A; RRM2; KIF2C; RFC4; KIF23; CENPF; NEK2;
DNA Replication 22 1.71367E-18 CENPE; KNTC1; KIF18A; MAD2L1; MCM4; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; CDC6; GINS2; CDC45; PLK4; CDCA8; KIF20A; KIF2C; RFC4; KIF23; CENPF; NEK2;
Mitotic M-M/G1 phases 20 1.48601E-16 CENPE; KNTC1; KIF18A; MAD2L1; MCM4; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; CDC6; CDC45; PLK4; CDCA8; KIF20A; KIF2C; KIF23; CENPF; NEK2;
M Phase 17 5.76137E-16 CENPE; KNTC1; KIF18A; MAD2L1; NUF2; CDK1; PLK1; CDC20; NDC80; BUB1; PLK4; CDCA8; KIF20A; KIF2C; KIF23; CENPF; NEK2;
Polo-like kinase signaling events in the cell cycle 14 2.77681E-14 CENPE; CCNB1; CDK1; AURKA; TPX2; ECT2; PLK1; PRC1; CDC20; NDC80; BUB1; PLK4; DLGAP5; KIF20A;
PLK1 signaling events 13 3.83583E-13 CENPE; CCNB1; CDK1; AURKA; TPX2; ECT2; PLK1; PRC1; CDC20; NDC80; BUB1; DLGAP5; KIF20A;
Mitotic Prometaphase 12 5.11023E-12 CENPE; KNTC1; KIF18A; MAD2L1; NUF2; PLK1; CDC20; NDC80; BUB1; CDCA8; KIF2C; CENPF;
Cell Cycle Checkpoints 11 1.32039E-08 MAD2L1; CCNB2; MCM4; NDC80; CCNB1; CDK1; CDC20; CDC6; CDC45; RFC4; CHEK1;
Signaling by Aurora kinases 11 1.04137E-10 NCAPH; NCAPG; AURKA; TPX2; NDC80; BUB1; CDCA8; DLGAP5; KIF20A; KIF2C; KIF23;
  1. Only pathways containing over 10 GDEs were listed