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Table 2 Causal association between blood pressure and midlife cognitive function inferred by inverse-variance weighted MR analysis

From: Association of blood pressure with cognitive function at midlife: a Mendelian randomization study

  DSST RAVLT Stroop
SBP DBP PP SBP DBP PP SBP DBP PP
IVW
Estimatea − 0.49 −0.66 − 0.52 − 0.04 − 0.04 − 0.07 0.15 0.18 0.16
95% CI −0.79, − 0.18 − 1.20, − 0.13 −0.99, − 0.04 −0.11, 0.03 − 0.16, 0.08 −0.18, 0.03 0.03, 0.32 −0.12, 0.48 − 0.11, 0.43
P-value 0.002 0.014 0.033 0.242 0.481 0.164 0.100 0.236 0.251
IVW after removing outliers
Estimatea − 0.49 −0.77 − 0.67 − 0.07 − 0.05 −0.07 0.23 0.24 0.27
95% CI −0.80, − 0.17 −1.03, − 0.23 − 1.16, − 0.18 − 0.14, 0.00 − 0.16, 0.06 −0.17, 0.03 0.05, 0.41 −0.07, 0.54 − 0.01, 0.56
P-value 0.002 0.005 0.008 0.046 0.37 0.165 0.011 0.126 0.058
  1. Abbreviations: IVW Inverse-variance weighted, MR Mendelian randomization, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, PP Pulse Pressure, DSST Digit Symbol Substitution Test, RAVLT Rey Auditory Verbal Learning Test, Stroop The Stroop Interference test
  2. a Represents the change in cognitive test score per 1-unit (mmHg) change in BP