BMC Medical Genomics

Table 2 Causal association between blood pressure and midlife cognitive function inferred by inverse-variance weighted MR analysis

From: Association of blood pressure with cognitive function at midlife: a Mendelian randomization study

	DSST			RAVLT			Stroop
	SBP	DBP	PP	SBP	DBP	PP	SBP	DBP	PP
IVW
Estimate^a	− 0.49	−0.66	− 0.52	− 0.04	− 0.04	− 0.07	0.15	0.18	0.16
95% CI	−0.79, − 0.18	− 1.20, − 0.13	−0.99, − 0.04	−0.11, 0.03	− 0.16, 0.08	−0.18, 0.03	0.03, 0.32	−0.12, 0.48	− 0.11, 0.43
P-value	0.002	0.014	0.033	0.242	0.481	0.164	0.100	0.236	0.251
IVW after removing outliers
Estimate^a	− 0.49	−0.77	− 0.67	− 0.07	− 0.05	−0.07	0.23	0.24	0.27
95% CI	−0.80, − 0.17	−1.03, − 0.23	− 1.16, − 0.18	− 0.14, 0.00	− 0.16, 0.06	−0.17, 0.03	0.05, 0.41	−0.07, 0.54	− 0.01, 0.56
P-value	0.002	0.005	0.008	0.046	0.37	0.165	0.011	0.126	0.058

Abbreviations: IVW Inverse-variance weighted, MR Mendelian randomization, SBP Systolic Blood Pressure, DBP Diastolic Blood Pressure, PP Pulse Pressure, DSST Digit Symbol Substitution Test, RAVLT Rey Auditory Verbal Learning Test, Stroop The Stroop Interference test
^a Represents the change in cognitive test score per 1-unit (mmHg) change in BP

Back to article page

ISSN: 1755-8794

Contact us

Submission enquiries: bmcmedicalgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com