Table 2 Nine differentially co-expressed genes which lost their hub statuses in one or multiple pathways
Gene | DCL ratea | p | q | Hub incidence | Pathways endorsing hub status |
|---|---|---|---|---|---|
AKR1C3 | 40% | 3.52E-40 | 1.05E-38 | 1 | Prostaglandin and Leukotriene metabolism |
ARF6 | 18% | 2.58E-17 | 4.25E-16 | 6 | Alpha4 beta1 integrin signaling events; Arf6 downstream pathway; Arf6 trafficking events; Integrin signaling pathway; Plexin-D1 Signaling; Posttranslational regulation of adherens junction stability and disassembly |
COL6A1 | 48% | 6.79E-152 | 1.11E-149 | 3 | Beta1 integrin cell surface interactions; Integrin signaling pathway; Syndecan-1-mediated signaling events |
HCK | 16% | 5.70E-08 | 6.19E-07 | 1 | Glypican 1 network |
ITPR1 | 14% | 0.00019113 | 0.0015595 | 4 | Alpha adrenergic receptor signaling pathway; Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin; GPCR GroupI metabotropic glutamate receptor signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway |
MAP 2 K7 | 36% | 3.18E-70 | 1.40E-68 | 7 | Cellular roles of Anthrax toxin; FAS (CD95) signaling pathway; IL-1 signaling pathway (through JNK cascade); IL-1 signaling pathway (through p38 cascade); Toll-like receptor signaling pathway (p38 cascade); Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade); Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade) |
SRCAP | 36% | 5.61E-97 | 3.88E-95 | 1 | Wnt signaling pathway |
TYK2 | 27% | 9.00E-37 | 2.47E-35 | 1 | IL-12 signaling (JAK2 TYK2 STAT4) |
VAV2 | 16% | 3.41E-08 | 3.83E-07 | 6 | CDC42 signaling events; E-cadherin signaling in the nascent adherens junction; EPHA2 forward signaling; Nectin adhesion pathway; Regulation of CDC42 activity; Regulation of RAC1 activity |