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Table 2 Nine differentially co-expressed genes which lost their hub statuses in one or multiple pathways

From: Expression correlation attenuates within and between key signaling pathways in chronic kidney disease

Gene DCL ratea p q Hub incidence Pathways endorsing hub status
AKR1C3 40% 3.52E-40 1.05E-38 1 Prostaglandin and Leukotriene metabolism
ARF6 18% 2.58E-17 4.25E-16 6 Alpha4 beta1 integrin signaling events; Arf6 downstream pathway; Arf6 trafficking events; Integrin signaling pathway; Plexin-D1 Signaling; Posttranslational regulation of adherens junction stability and disassembly
COL6A1 48% 6.79E-152 1.11E-149 3 Beta1 integrin cell surface interactions; Integrin signaling pathway; Syndecan-1-mediated signaling events
HCK 16% 5.70E-08 6.19E-07 1 Glypican 1 network
ITPR1 14% 0.00019113 0.0015595 4 Alpha adrenergic receptor signaling pathway; Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin; GPCR GroupI metabotropic glutamate receptor signaling pathway; Muscarinic acetylcholine receptor 1 and 3 signaling pathway
MAP 2 K7 36% 3.18E-70 1.40E-68 7 Cellular roles of Anthrax toxin; FAS (CD95) signaling pathway; IL-1 signaling pathway (through JNK cascade); IL-1 signaling pathway (through p38 cascade); Toll-like receptor signaling pathway (p38 cascade); Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, JNK cascade); Toll-like receptor signaling pathway (through ECSIT, MEKK1, MKKs, p38 cascade)
SRCAP 36% 5.61E-97 3.88E-95 1 Wnt signaling pathway
TYK2 27% 9.00E-37 2.47E-35 1 IL-12 signaling (JAK2 TYK2 STAT4)
VAV2 16% 3.41E-08 3.83E-07 6 CDC42 signaling events; E-cadherin signaling in the nascent adherens junction; EPHA2 forward signaling; Nectin adhesion pathway; Regulation of CDC42 activity; Regulation of RAC1 activity
  1. a proportion of Differentially Coexpressed Links (DCLs) in total incident links