Table 4 Features of genomic alterations in colon polyps
Genomic alterations | Pathological diagnoses of colon polyps / (N) | |||||
|---|---|---|---|---|---|---|
AC/ | HYP/ | SA/ | TA/ | TVA/ | VA/ | |
32 | 17 | 16 | 80 | 40 | 13 | |
APC mutation | ||||||
+ Frameshift | 10 | 1 | 0 | 19 | 13 | 5 |
+ Nonsense | 5 | 1 | 2 | 15 | 8 | 1 |
+ Nonsense and Frameshift | 1 | 0 | 0 | 0 | 0 | 0 |
+ Missense and Frameshift | 0 | 0 | 0 | 1 | 1 | 0 |
+ Nonsense and Missense | 0 | 0 | 0 | 2 | 0 | 0 |
Total | 16 | 2 | 2 | 37 | 22 | 6 |
KRAS mutation | ||||||
+ Codon 12 | 8 | 2 | 2 | 4 | 13 | 6 |
+ Codon 13 | 2 | 0 | 0 | 3 | 2 | 4 |
+ Both | 1 | 0 | 0 | 0 | 0 | 0 |
Total | 11 | 2 | 2 | 7 | 15 | 10 |
20q13.33 copy number | ||||||
+ Loss | 0 | 0 | 0 | 3 | 1 | 0 |
+ Gain | 20 | 14 | 11 | 52 | 19 | 8 |
Total | 20 | 14 | 11 | 55 | 20 | 8 |
MSI status | ||||||
+ MSS | 22 | 12 | 10 | 67 | 29 | 8 |
+ MSI-L | 4 | 1 | 2 | 12 | 6 | 4 |
+ MSI-H | 6 | 4 | 4 | 1 | 5 | 1 |
Total | 32 | 17 | 16 | 80 | 40 | 13 |