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Table 4 Features of genomic alterations in colon polyps

From: Genomic amplification of chromosome 20q13.33 is the early biomarker for the development of sporadic colorectal carcinoma

Genomic alterations Pathological diagnoses of colon polyps / (N)
AC/ HYP/ SA/ TA/ TVA/ VA/
32 17 16 80 40 13
APC mutation
 + Frameshift 10 1 0 19 13 5
 + Nonsense 5 1 2 15 8 1
 + Nonsense and Frameshift 1 0 0 0 0 0
 + Missense and Frameshift 0 0 0 1 1 0
 + Nonsense and Missense 0 0 0 2 0 0
Total 16 2 2 37 22 6
KRAS mutation
 + Codon 12 8 2 2 4 13 6
 + Codon 13 2 0 0 3 2 4
 + Both 1 0 0 0 0 0
Total 11 2 2 7 15 10
20q13.33 copy number
 + Loss 0 0 0 3 1 0
 + Gain 20 14 11 52 19 8
Total 20 14 11 55 20 8
MSI status
 + MSS 22 12 10 67 29 8
 + MSI-L 4 1 2 12 6 4
 + MSI-H 6 4 4 1 5 1
Total 32 17 16 80 40 13
  1. Abbreviations: AC Adenocarcinoma, HYP Hyperplastic polyp, SA Serrated adenoma, TA Tubular adenoma, TVA Tubulovillous adenoma, VA Villous adenoma