Table 1 Functions and mutational specificities of novel cancer-associated genes in IDBC
From: Stage-specific protein-domain mutational profile of invasive ductal breast cancer
Genes | Canonical functions | Cancer relevance | Specificity | Â |
|---|---|---|---|---|
| Â | Â | Â | Stage | In situ |
CFBF | The encoded transcription factor | Function in | Stage I | No |
| Â | regulates RUNX and other genes | aberrant estrogen | Â | Â |
| Â | specific to hematopoiesis | receptor signaling | Â | Â |
MAP2K4, | The encoded kinases belong to a | Evading apoptosis, | No | Duct |
MAP3K4 | protein kinase signal transduction | Dysfunction of DNA | Stage | Duct |
| Â | cascade, which can activate the | repair mechanism | Â | Â |
| Â | stress-induced P38 and JNK | Â | Â | Â |
| Â | MAPK pathways | Â | Â | Â |
NCOA3 | The encoded protein (AIB1) | Biomarker for | No | No |
| Â | enhances estrogen-dependent | evaluating | Â | Â |
| Â | transcription | tamoxifen [24] | Â | Â |
RB1 | RB1 prevents excessive cell growth | A tumor suppressor | No | Duct |
| Â | by inhibiting cell cycle progression | that controls cell | Â | Â |
| Â | until a cell is ready to divide | growth [25] | Â | Â |
ZNF384 | The encoded transcription factor | Involved in cell | Stage I | Duct |
| Â | involved in extracellular matrix | proliferation in | Â | Â |
| Â | remodeling | other cancers | Â | Â |