Fig. 3

Different hubs in tumorigenesis and drug resistance. Node degree means the number of interaction partners a gene had in the PPI network. “Old” represents the initial set of genes mutated pre-pazopanib resistance; “New” represents the newly mutated genes post-pazopanib resistance; “All” represents all genes in the PPI network as the background for comparison. a Newly mutated genes (post-pazopanib resistance) tended to be smaller hubs than the “old” genes(p < 0.05). b New mutations were more clustered. Clustering coefficient (CC) counted the fraction of realized interactions out of all possible pair-wise interactions among the direct neighbors of a given node. Newly mutated genes post-pazopanib resistance (“New”) had significantly higher CC than those pre-pazopanib resistance (“Old”) (p < 0.05)