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Table 4 Candidate drugs targeting key genes

From: Identification of intestinal flora-related key genes and therapeutic drugs in colorectal cancer

Gene Drug Score* Refs. (PMID)
CSF2 Interferon alfa-2b 2 10522033
CSF2 Mechlorethamine 2 10640980
CSF2 Streptozotocin 2 16342200
CSF2 Procarbazine 2 10640980
CSF2 Temozolomide 3 12610499, 16100942
CSF2 Mycophenolic acid 2 9822358
CSF2 Nordihydroguaiaretic acid 2 2453577
CSF2 Idarubicin 2 8915668
CSF2 Cytarabine 3 8819077, 8450676
CSF2 Vinblastine 2 10640980
CXCL8 Paclitaxel 2 9271387
CXCL8 Bevacizumab 1
CXCL8 Aspirin 2 12576442
CXCL8 Leflunomide 2 10902750
CXCL8 Tretinoin 2 8900181
CXCL8 Cetuximab 4 10614716, 15908664, 10037173
CXCL8 Medroxyprogesterone acetate 2 15914533
CXCL8 Cyclophosphamide 1
CXCL8 Verapamil 2 2686646
IL6R Oprelvekin 1
IL6R Tocilizumab 8 16899109
IL6R Fluorouracil 2 8888499
IL6R Thalidomide 2 12515619
CXCL10 Oxaliplatin 2 16101140
  1. *The score is the combined number of database sources and PubMed references supporting a given interaction