In silico pathway analysis based on chromosomal instability in breast cancer patients

BMC Medical Genomics

Table 2 Comparison of cytogenetic profile of Breast cancer patients stage-wise and matched controls

S.No	Patient group and controls	Mean (%) TAM	Mean (%) MSA	Mean (%) MNA	Mean (%) M(SA + NA)#	Mean MAA (%)
1	Stage I cases (n = 20) Controls (n = 20) p-value	20.6 ± 7.6 10.3 ± 3.0 < 0.0001	9.3 ± 5.8 4.7 ± 3.1 0.0034	9.2 ± 5.0 4.5 ± 3.2 0.0011	3.0 ± 2.3 1.2 ± 1.1 0.0031	28.6 ± 13.5 30.2 ± 11.8 0.069
2	Stage II cases (n = 74)* Controls (n = 74) p-value	12.0 ± 9.2 12.9 ± 5.0 0.4609	13.1 ± 9.2 4.7 ± 3.2 < 0.0001	9.4 ± 6.2 6.3 ± 3.4 0.0002	2.2 ± 1.5 2.0 ± 1.4 0.4031	28.3 ± 15.0 29.6 ± 15.0 0.5989
3	Stage III cases(n = 37) Control (n = 37) p-value	21.7 ± 12.1 11.9 ± 4.1 < 0.0001	10.6 ± 7.9 4.1 ± 2.8 0.0015	9.4 ± 7.5 6.3 ± 3.4 0.0250	3.5 ± 2.8 1.5 ± 1.2 0.0002	26.0 ± 13.2 18.9 ± 17.9 0.0561
4	Stage IV cases (n = 14) Controls (n = 14) p-value	22.2 ± 9.7 13.8 ± 5.1 0.0081	10.9 ± 7.2 5.1 ± 3.5 0.0117	10.2 ± 9.2 6.8 ± 3.9 0.2142	2.1 ± 1.0 1.9 ± 1.8 0.7192	31.6 ± 19.3 26.1 ± 18.5 0.4484
5	Indeterminate stage cases (n = 5) Controls (n = 5) p-value	16.7 ± 2.4 13.0 ± 5.5 0.2053	4.7 ± 3.3 3.7 ± 2.2 0.5883	11.5 ± 3.3 7.7 ± 4.8 0.1828	1.0 ± 0.0 1.6 ± 1.5 0.3972	24.6 ± 8.1 26.0 ± 14.0 0.8514

Significant p-value (< 0.05), calculated by t-test, are shown in bold
TAM total aberrant metaphases, MSA metaphases with structural aberrations, MNA metaphases with numerical aberrations, M(SA + NA): metaphases with structural and numerical aberrations, MAA metaphases with acrocentric associations
^*One of the subjects with Stage II breast cancer had more than 90% frequency of structural aberration as it was a clonal chromosomal anomaly. Therefore, it was not included in the calculations. Similarly, one of the subjects with Indeterminate stage had a very higher frequency of structural aberrations, thus, it was not included in the calculations
^# The zero values were omitted during the calculation of Average and Standard Deviation due to the presence of high number of zero values in Mean(%) M(SA + NA)

ISSN: 1755-8794