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Table 1 The basic clinical characteristics of the object of study

From: Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family

 

Case 1

Case 2

Case 3

Case 4

Case 5

Con 1

Con 2

Year (2015)

Death

56

54

52

17

45

21

Sex

Female

Female

Female

Female

Male

Male

Female

Year of initial diagnosis

1990

2006

2007

1992

2014

Smoking

Drinking

Clinical manifestation

       

Heart

 + 

 + 

 + 

 + 

 + 

Proptosis

 + 

 + 

 + 

 + 

Hands tremble

 + 

 + 

 + 

 + 

 + 

Goiter

 + 

 + 

 + 

Ophthalmopathy

 + 

Serological test

       

FT3 (pmol/L)

3.26

4.76

6.86

2.39

9.85

4.49

4.70

FT4 (pmol/L)

16.57

17.60

21.61

7.71

26.50

16.45

15.94

TSH (mUL/L)

 < 0.005

0.118

 < 0.005

62.10

0.072

1.18

0.740

TRAb (IU/L)

2.38

4.13

5.75

1.27

1.04

Treatment

Thiamazole

Thiamazole

Thiamazole

I131

Thiamazole

  1.  +: positive; −: negative