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Table 1 The basic clinical characteristics of the object of study

From: Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family

  Case 1 Case 2 Case 3 Case 4 Case 5 Con 1 Con 2
Year (2015) Death 56 54 52 17 45 21
Sex Female Female Female Female Male Male Female
Year of initial diagnosis 1990 2006 2007 1992 2014
Smoking
Drinking
Clinical manifestation        
Heart  +   +   +   +   + 
Proptosis  +   +   +   + 
Hands tremble  +   +   +   +   + 
Goiter  +   +   + 
Ophthalmopathy  + 
Serological test        
FT3 (pmol/L) 3.26 4.76 6.86 2.39 9.85 4.49 4.70
FT4 (pmol/L) 16.57 17.60 21.61 7.71 26.50 16.45 15.94
TSH (mUL/L)  < 0.005 0.118  < 0.005 62.10 0.072 1.18 0.740
TRAb (IU/L) 2.38 4.13 5.75 1.27 1.04
Treatment Thiamazole Thiamazole Thiamazole I131 Thiamazole
  1.  +: positive; −: negative