Table 2 KEGG analysis of the main enriched signal pathways of differential genes between low-risk group and high-risk group

hsa00830

Retinol metabolism

15/303

67/6589

2.43E−07

3.65E−05

3.02E−05

hsa04080

Neuroactive ligand-receptor interaction

36/303

340/6589

1.79E−06

0.000134

0.000111

hsa04512

ECM-receptor interaction

15/303

88/6589

9.28E−06

0.000464

0.000384

hsa00982

Drug metabolism—cytochrome P450

12/303

72/6589

9.22E−05

0.003457

0.002862

hsa04024

cAMP signaling pathway

22/303

216/6589

0.000351

0.010534

0.008723

hsa04610

Complement and coagulation cascades

12/303

85/6589

0.000462

0.011548

0.009563

hsa04640

Hematopoietic cell lineage

13/303

99/6589

0.000554

0.011874

0.009832

hsa00040

Pentose and glucuronate interconversions

7/303

34/6589

0.000746

0.012988

0.010755

hsa00360

Phenylalanine metabolism

5/303

17/6589

0.000779

0.012988

0.010755

hsa00350

Tyrosine metabolism

7/303

36/6589

0.00107

0.016002

0.013251

hsa00053

Ascorbate and aldarate metabolism

6/303

27/6589

0.001173

0.016002

0.013251

hsa04260

Cardiac muscle contraction

11/303

86/6589

0.001815

0.022681

0.018782

hsa00590

Arachidonic acid metabolism

9/303

63/6589

0.00216

0.024919

0.020635

hsa00980

Metabolism of xenobiotics by cytochrome P450

10/303

76/6589

0.002343

0.025099

0.020784

hsa00860

Porphyrin and chlorophyll metabolism

7/303

42/6589

0.002731

0.027309

0.022614

hsa00983

Drug metabolism—other enzymes

10/303

79/6589

0.003131

0.029357

0.024309

hsa00500

Starch and sucrose metabolism

6/303

36/6589

0.005453

0.048118

0.039845