Fig. 4
![Fig. 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12920-020-0657-6/MediaObjects/12920_2020_657_Fig4_HTML.png)
The UPUP-only group shows a weaker correspondence to the UPUP pattern compared to the UPDOWN-only group and the corresponding UPDOWN pattern, although a clear difference between two groups can be seen. Most of the UPDOWN-only DNA methylation probes are negatively correlated with the expression of corresponding genes, while a few are positively correlated positively. UPUP-only pattern includes some negatively correlated probes, but still the larger fraction shows positive correlation. Overall, the UPUP and UPDOWN patterns are clearly distinct