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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Impact of mutations in DNA methylation modification genes on genome-wide methylation landscapes and downstream gene activations in pan-cancer

Fig. 3

Genome-wide landscape of promoter methylation. Differential methylation level of gene promoter regions are profiled for 9 cancer types: bladder cancer (BLCA), breast cancer (BRCA), colon adenocarcinoma (COAD), head and neck squamous carcinoma (HNSC), kidney renal carcinoma (KIRC), acute myeloid leukemia (LAML), lung adenocarcinoma (LUAD), lung squamous carcinoma (LUSC), and uterine corpus endometrial carcinoma (UCEC). 9,580 genes showed hyper-methylation (red) or hypo-methylation (blue) in the promoter regions for at least one cancer type. In the lower panel, genes (i.e., column of the figure) are ordered according to the chromosomal position, and cancer types (i.e., row of the figures) are sorted by lexicographic order. In the upper panel, genes and cancer types are clustered in terms of methylation profile similarity

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BMC Medical Genomics

ISSN: 1755-8794

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