Fig. 1

Global Expression Pattern of IAPs. The 7 IAPs have distinct expression pattern across 32 cancer types. Using GBM as an example, hierarchical clustering (b) using Ward’s linkage and correlation-based distance identified 2 clusters based on the criteria of maximum average Silhouette width (a). c Divergent correlation among the 7 IAPs in GBM. d Example association between XIAP and BIRC6 among 32 cancer types. All these correlations are statistically significant with p < 0.001. e A global view of the similarity of IAP expression patterns. The upper right triangle shows the frequency of any pair of IAPs being clustered together among 32 cancers. The lower left triangle shows the average correlation between any 2 pair of IAPs. Circle size indicate magnitude (frequency or correlation). Color indicates correlation direction, with red for positive correlation, blue for negative correlation and values indicated in the color legend. All correlations are computed using Spearman rank correlation