Fig. 1

Overview of AMLVaran’s system architecture. Uploaded raw sequencing data are processed by the mutation calling pipeline and the resulting variants are stored in the database. For display at the web interface, the variants are compared with predefined mutation sites and combined with the most up-to-date information from annotation tables. Afterwards, the output is presented in form of a dynamic mutation explorer with comprehensive filter settings. A standardized clinical report is generated from the predefined driver mutation sites as well