Skip to main content
Fig. 3 | BMC Medical Genomics

Fig. 3

From: Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection

Fig. 3

Top 10 pathways ranked by statistical significance. Top 10 pathways ranked by p-values (vertical bars) in three conditions. Vertical axis denotes statistical significance as measured by minus logarithm of p-values. Blue bars are downregulated pathways; red bars are upregulated pathways. a Moderate influenza patients compared to healthy controls. Upregulated pathways correspond to activation of interferon and neutrophil themes. Downregulated pathway corresponds to the immune response theme. b Severe influenza patients compared to healthy controls. Upregulated pathways correspond to activation of interferon and neutrophil themes. Downregulated pathway corresponds to the immune response theme. c Severe influenza patients compared to moderate influenza patients. Upregulated pathways correspond to activation of neutrophil and cell cycle (delayed apoptosis) themes. Downregulated pathway corresponds to the immune response theme

Back to article page
\