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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection

Fig. 3

Top 10 pathways ranked by statistical significance. Top 10 pathways ranked by p-values (vertical bars) in three conditions. Vertical axis denotes statistical significance as measured by minus logarithm of p-values. Blue bars are downregulated pathways; red bars are upregulated pathways. a Moderate influenza patients compared to healthy controls. Upregulated pathways correspond to activation of interferon and neutrophil themes. Downregulated pathway corresponds to the immune response theme. b Severe influenza patients compared to healthy controls. Upregulated pathways correspond to activation of interferon and neutrophil themes. Downregulated pathway corresponds to the immune response theme. c Severe influenza patients compared to moderate influenza patients. Upregulated pathways correspond to activation of neutrophil and cell cycle (delayed apoptosis) themes. Downregulated pathway corresponds to the immune response theme

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BMC Medical Genomics

ISSN: 1755-8794

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