Table 2 Pathways enriched in EW_dmGWAS module genes (European dataset)
Pathway ID | Pathway name | Pathway size* | # informative genes$ | Adjusted p-value# |
|---|---|---|---|---|
GO Biological Process | ||||
 GO:0002768 | Immune response-regulating cell surface receptor signaling pathway | 330 | 23 | 2.3 × 10−6 |
 GO:0003012 | Muscle system process | 423 | 25 | 1.2 × 10− 5 |
 GO:1905475 | Regulation of protein localization to membrane | 177 | 15 | 2.3 × 10−4 |
 GO:0030335 | Positive regulation of cell migration | 472 | 24 | 4.5 × 10− 4 |
 GO:0022898 | Regulation of transmembrane transporter activity | 235 | 16 | 1.7 × 10−3 |
 GO:0090068 | Positive regulation of cell cycle process | 270 | 17 | 2.1 × 10−3 |
 GO:0043433 | Negative regulation of DNA-binding transcription factor activity | 155 | 13 | 2.1 × 10−3 |
 GO:0060627 | Regulation of vesicle-mediated transport | 499 | 23 | 4.8 × 10−3 |
 GO:0032956 | Regulation of actin cytoskeleton organization | 320 | 18 | 5.0 × 10−3 |
 GO:0010975 | Regulation of neuron projection development | 475 | 22 | 7.8 × 10−3 |
 GO:0002433 | Immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 76 | 9 | 8.0 × 10−3 |
KEGG pathway | ||||
 hsa05215 | Prostate cancer | 97 | 14 | 2.8 × 10−6 |
 hsa04666 | Fc gamma R-mediated phagocytosis | 91 | 13 | 1.1 × 10−5 |
 hsa05211 | Renal cell carcinoma | 69 | 11 | 4.1 × 10−5 |
 hsa04662 | B cell receptor signaling pathway | 71 | 8 | 0.030 |
 hsa05214 | Glioma | 71 | 8 | 0.030 |