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Table 2 Pathways enriched in EW_dmGWAS module genes (European dataset)

From: An integrative, genomic, transcriptomic and network-assisted study to identify genes associated with human cleft lip with or without cleft palate

Pathway IDPathway namePathway size*# informative genes$Adjusted p-value#
GO Biological Process
 GO:0002768Immune response-regulating cell surface receptor signaling pathway330232.3 × 10−6
 GO:0003012Muscle system process423251.2 × 10− 5
 GO:1905475Regulation of protein localization to membrane177152.3 × 10−4
 GO:0030335Positive regulation of cell migration472244.5 × 10− 4
 GO:0022898Regulation of transmembrane transporter activity235161.7 × 10−3
 GO:0090068Positive regulation of cell cycle process270172.1 × 10−3
 GO:0043433Negative regulation of DNA-binding transcription factor activity155132.1 × 10−3
 GO:0060627Regulation of vesicle-mediated transport499234.8 × 10−3
 GO:0032956Regulation of actin cytoskeleton organization320185.0 × 10−3
 GO:0010975Regulation of neuron projection development475227.8 × 10−3
 GO:0002433Immune response-regulating cell surface receptor signaling pathway involved in phagocytosis7698.0 × 10−3
KEGG pathway
 hsa05215Prostate cancer97142.8 × 10−6
 hsa04666Fc gamma R-mediated phagocytosis91131.1 × 10−5
 hsa05211Renal cell carcinoma69114.1 × 10−5
 hsa04662B cell receptor signaling pathway7180.030
 hsa05214Glioma7180.030
  1. *Pathway size: the total number of genes in the GO term or KEGG pathway
  2. $The observed number of genes from the module gene list
  3. #Bonferroni method was used to adjust p-value