Table 1 Top 15 potential shared neoantigens based on TCGA-SKCM cohort. Recurrent mutations observed on TCGA-SKCM cohort. The amino acid (AA) residue changes caused by somatic mutations are highlighted in the (neo) epitopes sequences. The frequency represents the number of samples showing the corresponding mutation
From: neoANT-HILL: an integrated tool for identification of potential neoantigens
Gene | AA change | Neoepitope | HLA haplotype | Frequency |
|---|---|---|---|---|
RAC1 | P29S | FSGEYITV | HLA-A*02:01 | 17/466 |
KLHDC7A | E635K | HTATVRAKK | HLA-A*11:01 | 12/466 |
INMT | S212F | YMVGKREFFCV | HLA-A*02:01 | 9/466 |
CDH6 | S524L | FLFSLAPEAA | HLA-A*02:01 | 8/466 |
ZBED2 | E157K | GTMALWASQRK | HLA-A*11:01 | 8/466 |
CRNKL1 | S128F | LQVPLPVPRF | HLA-A*15:01 | 7/466 |
IL37 | S202L | FLFQPVCKA | HLA-A*02:01 | 7/466 |
SERPINB3 | E250K | LSMIVLLPNK | HLA-A*11:01 | 6/466 |
DNAJC5B | E22K | STTGEALYK | HLA-A*11:01 | 6/466 |
MYO7B | E512K | MSIISLLDK | HLA-A*11:01 | 6/466 |
MORC1 | E878K | IQNTYMVQYK | HLA-A*11:01 | 6/466 |
SCN7A | S445F | IEMKKRSPIF | HLA-A*15:01 | 6/466 |
PSG9 | E404K | KISKSMTVK | HLA-A*11:01 | 6/466 |
RAC1 | P29L | FLGEYIPTV | HLA-A*02:01 | 5/466 |
NUTF2 | Q20K | SSFIQHYYK | HLA-A*11:01 | 5/466 |