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Table 7 Results for interactions reported by Liu et al. [2]

From: Modified entropy-based procedure detects gene-gene-interactions in unconventional genetic models

SNP pair

p SNP 1

Gene 1

p SNP 2

Gene 2

Submodel

LD

TS pair

p value

rs9275595:rs10807113

9.50E-63

DQA2 (F5U)

1.30E-05

DQB2 (F3U)

Multi

0.0026

0.03843

4.08E-20

rs9275390:rs10807113

1.22E-56

DQA2 (F5U)

1.30E-05

DQB2 (F3U)

Multi

0.0001

0.039163

1.51E-20

rs9275390:rs2051549

1.22E-56

DQA2 (F5U)

4.96E-01

DQB2 (Intron)

Multi

0.0074

0.029437

7.13E-15

rs2858332:rs10807113

2.90E-06

DQA2 (F5U)

1.30E-05

DQB2 (F3U)

Epi

0.0082

0.043533

4.01E-23

rs7774434:rs10807113

5.09E-19

DQA1 (F3U)

1.30E-05

DQB2 (F3U)

Multi

0.0035

0.029443

7.07E-15

rs7774434:rs2051549

5.09E-19

DQA1 (F3U)

4.96E-01

DQB2 (Intron)

Multi

0.0011

0.042317

2.10E-22

rs9275390:rs6901084

1.22E-56

DQA2 (F5U)

1.39E-02

DQB2 (F5U)

Epi

0.0088

0.025216

1.89E-12

rs2858332:rs6901084

2.90E-06

DQA2 (F5U)

1.39E-02

DQB2 (F5U)

Multi

0.0091

0.043533

2.90E-21

  1. Submodel of interaction as detailed in Table 6, p SNP 1 and p SNP 2 as p-values from 1st order calculation,
  2. linkage disequilibrium (LD) between SNPs, TS pair as value of the test statistic from 2nd order calculation,
  3. p-value as result from 2nd order calculation