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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

Fig. 4

The tissue origins of cfDNA following APAP overdose in mouse models. Barplots of concentration of blood biomarkers from APAP-injected hepatocyte-specific knockout mice (n = 4) and saline-treated negative control (n = 10, pooled): a total cell-free DNA, b bilirubin, c AST, d ALT, e albumin. Data are shown as mean ± standard error. f H&E staining of liver tissues from an APAP-injected hepatocyte-specific knockout mice vs saline-treated negative control showing acute zone 3 coagulative necrosis typical of APAP hepatotoxicity. g Comparison of hepatocyte cell contribution in healthy mice vs post APAP overdose (n = 4)

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BMC Medical Genomics

ISSN: 1755-8794

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