Fig. 3

Karyoviews from microarray results at the time of diagnosis and relapse. a Microarray results revealing a deletion of fragment of the long arm of chromosome 13 (13q12.2-q21.1) containing the RB1 gene (red box), PAX5 intragenic deletion and NOTCH1 intragenic duplication (both on chromosome 9). b Microarray results revealing that 13q deletion was not found in samples from relapse. In addition to the PAX5 and NOTCH1 alterations, CDKN2A/B deletion (red box) and 22 trisomy (blue box) were also observed. Asterisks correspond to deletion (red colour), duplication (blue colour) and loss of heterozygosity (purple colour)