Table 3 Pathways enriched in genes generating circRNAs expressed predominantly in human pancreatic islets
A. | |||
Pathways enriched in genes hosting circRNAs not seen in other tissues | |||
Pathway | p-value | Number of Genes | Genes |
Pancreatic secretion | < 0.0001 | 5 | CELA3A, CFTR, CPA1, KCNQ1, PNLIPRP2 |
B. | |||
Pathways enriched in genes generating the top 10% the most abundantly-expressed circRNAs in islets | |||
Pathway | p-value | Number of Genes | Genes |
Hematopoietic Stem Cell Gene Regulation | < 0.0001 | 4 | CREBBP, EP300, FOXO3, GABPB1 |
Pathways affected in Adenoid Cystic Carcinoma | 0.010 | 6 | CREBBP,EP300, FOXO3, KANSL1, KMT2C, MAML3 |
Attenuation phase | 0.020 | 3 | CREBBP, DNAJB1, EP300 |
RUNX3 regulates NOTCH signaling | 0.020 | 3 | CREBBP, EP300, MAML3 |
Lysine degradation | 0.030 | 5 | ASHIL, EHMT1, KMT2C, PLOD1, SETD3 |