Fig. 1

Genomic survey with two-step geomapping approach identifies amplification-associated transcription coupling (ATC) loci clustered in seven genomic regions. a. Example genes with high correlation coefficients between copy-number and expression levels. b. Example region aggregated with genes of expression and copy-number correlation coefficients ≥0.6 (referred as ATC loci) identified by the optimal univariate k-means clustering method. c. Expression profiles of ATC loci in the seven identified genomic regions by tumor (n = 1014) and normal controls (n = 96). d. Average normalized expression of ATC loci in the seven genomic regions by the status of estrogen receptor α (ERα). Pearson correlation coefficients (r) and P-values are shown (*P < 0.05, **P < 0.01, ***P < 0.001)