Table 8 The association studies regarding methamphetamine and BDNF/PICK1 gene polymorphisms in the methamphetamine abusers and controls
Gene-SNP | Ethnicity | Sample size | Result | Refs | |
|---|---|---|---|---|---|
Meth | Normal | ||||
BDNF-Val66Met | Chinese | 200 | 219 | No significant differences in genotype and allele. The Met allele was associated with earlier age onset of METH use | [52] |
BDNF-rs16917204, rs16917234, rs2030324 | Chinese | 200 | 219 | No significant differences in genotype and allele distributions | [53] |
BDNF-Val66Met | Taiwanese | 103 | 200 | Significant differences in BDNF Val66Met genotype distribution | [21] |
BDNF-Val66Met (rs6265) | Thai | 100 | 102 | Significant differences in the distribution of rs6265 genotype A lower frequency of GG genotype associated with METH-induced psychosis | [20] |
BDNF promoter methylation | Chinese | 30 | 52 | BDNF promoter methylation is associated with drug addiction | [54] |
BDNF-Val66Met | Chinese | 194 | 378 | No significant differences in genotype and allele distributions A significant positive correlation between serum BDNF and the delayed memory index score | [55] |
BDNF-Val66Met | Japanese | 189 | 202 | No significant differences were found in the frequency of the genotype or allele | [56] |
BDNF-Val66Met | Chinese | 24 | 45 | A significant distribution of the BDNF Val66Met genotype with METH dependence and METH psychosis in Chinese | [22] |
Malay | 59 | 51 | |||
Kadazan-Dusun | 50 | 30 | |||
Bajau | 53 | 28 | |||
Total | 186 | 154 | |||
BDNF-Val66Met | Caucasian | 60 | None | Significantly more pretreatment days with METH use in females than males A significant association between females with Val/Val genotype and METH use | [57] |
PICK1- s737622, rs3026682, rs713729, rs2076369 | Japanese | 208 | 218 | A significantly association between: -rs713729 and METH abusers -rs713729 and rs2076369 with spontaneous relapse of psychosis | [16] |