|
Gene regulation in HCC compared with NT
|
HCC subtype
|
Master molecule name
|
Reached from input set
|
FDR
|
Median FC gene expression in GE1-HCC
|
Median FC gene expression in GE2-HCC
|
|---|
| | |
TGM2
|
10
|
0.001
|
NC
|
NC
|
| |
GE1
|
MMP15
|
9
|
0.001
|
NC
|
NC
|
|
UP
| |
E2F1
|
8
|
0.003
|
1.97
|
6.43
|
| | |
CCNB2
|
225
|
0.001
|
NC
|
8.02
|
| |
GE2
|
APC/C
|
219
|
0.001
|
NCa
|
2.20a
|
| | |
PKMYT1
|
232
|
0
|
NC
|
4.05
|
| | |
SOCS3
|
51
|
0
|
− 2.03
|
− 1.95
|
| |
GE1
|
CD4
|
40
|
0
|
− 2.03
|
NC
|
|
DOWN
| |
IL10
|
56
|
0
|
NC
|
NC
|
| | |
TNF
|
147
|
0
|
NC
|
NC
|
| |
GE2
|
GRK5
|
96
|
0
|
NC
|
− 2.51
|
| | |
IL10
|
134
|
0
|
NC
|
NC
|
- “Reached from input set”—the number of genes from the input list present in the network of this master molecule.
- FC fold change, FDR false discovery rate, HCC hepatocellular carcinoma, NC no change, NT non-tumourous
- aFC is shown for APC subunit ANAPC11
