Skip to main content

Table 6 Top three master regulators upstream of dysregulated genes in GE1-HCC and GE2-HCC

From: Gene networks and transcriptional regulators associated with liver cancer development and progression

Gene regulation in HCC compared with NT HCC subtype Master molecule name Reached from input set FDR Median FC gene expression in GE1-HCC Median FC gene expression in GE2-HCC
   TGM2 10 0.001 NC NC
  GE1 MMP15 9 0.001 NC NC
UP   E2F1 8 0.003 1.97 6.43
   CCNB2 225 0.001 NC 8.02
  GE2 APC/C 219 0.001 NCa 2.20a
   PKMYT1 232 0 NC 4.05
   SOCS3 51 0 − 2.03 − 1.95
  GE1 CD4 40 0 − 2.03 NC
DOWN   IL10 56 0 NC NC
   TNF 147 0 NC NC
  GE2 GRK5 96 0 NC − 2.51
   IL10 134 0 NC NC
  1. “Reached from input set”—the number of genes from the input list present in the network of this master molecule.
  2. FC fold change, FDR false discovery rate, HCC hepatocellular carcinoma, NC no change, NT non-tumourous
  3. aFC is shown for APC subunit ANAPC11